Human Genetics

, Volume 92, Issue 5, pp 441–445

Molecular and cytogenetic analyses of autism in Taiwan

  • Shuan-Yow Li
  • Yung-Cheng Joseph Chen
  • Te-Jen Lai
  • Chuan-Yu Hsu
  • Yi-Chun Wang
Original Investigations

DOI: 10.1007/BF00216447

Cite this article as:
Li, S., Chen, Y.J., Lai, T. et al. Hum Genet (1993) 92: 441. doi:10.1007/BF00216447

Abstract

Karyotypic and DNA analyses were both performed on 104 autistic children referred from Taichung Autism Education Academy and Tainan Autism Association in Taiwan. The frequency of fragile sites of the autistic patients did not differ significantly from that of the normal individuals. Of the 12 autistic children with chromosomal abnormalities, 8 had the fragile X, 2 had Down syndrome, and the remaining had other aneuploid constitutions. The results of this study illustrate the contribution of chromosomal abnormalities or variants to the pathogenesis of infantile autism.

Copyright information

© Springer-Verlag 1993

Authors and Affiliations

  • Shuan-Yow Li
    • 1
  • Yung-Cheng Joseph Chen
    • 2
  • Te-Jen Lai
    • 2
  • Chuan-Yu Hsu
    • 1
  • Yi-Chun Wang
    • 1
  1. 1.Cytogenetics LaboratoryChung Shan Medical and Dental CollegeTaichungTaiwan, Republic of China
  2. 2.Department of Psychiatry, Medical CollegeNational Cheng-Kung UniversityTainanTaiwan, Republic of China