Dietary exposure of mink to carp from Saginaw Bay, Michigan: 2. Hematology and liver pathology

  • S. N. Heaton
  • S. J. Bursian
  • J. P. Giesy
  • D. E. Tillitt
  • J. A. Render
  • P. D. Jones
  • D. A. Verbrugge
  • T. J. Kubiak
  • R. J. Aulerich
Article

DOI: 10.1007/BF00212509

Cite this article as:
Heaton, S.N., Bursian, S.J., Giesy, J.P. et al. Arch. Environ. Contam. Toxicol. (1995) 29: 411. doi:10.1007/BF00212509

Abstract

The effects of consumption of environmental contaminants contained in carp (Cyprinus carpio) from Saginaw Bay, Michigan on various hematological parameters and liver integrity of adult female mink (Mustela vison) were determined. Mink were fed diets that contained 0 (control), 10, 20, or 40% carp prior to and throughout the reproductive period (182 days). The diets contained 0.015, 0.72, 1.53, and 2.56 mg polychlorinated biphenyls (PCBs)/kg diet and 1.0, 19, 40, and 81 pg 2,3,7,8-tetrachlorodibenzo-p-dioxin equivalents (TEQs)/g diet, respectively. Mink fed the diets containing carp showed a general dose-dependent occurrence of clinical signs commonly associated with chlorinated hydrocarbon toxicity, including listlessness, nervousness when approached, anorexia, and melena. Erythrocyte counts were less in mink exposed to Saginaw Bay carp than in controls, while the number of white blood cells was greater than in controls. Significant differences (p<0.05) in the concentrations of neutrophils, lymphocytes, monocytes, and eosinophils were also found between the control and carp-fed groups, but are considered to be of limited clinical or biological importance. Hematocrit values for the mink fed the 20 and 40% carp diets were significantly less than those of mink in the control and 10% carp groups. There were no significant differences in hemoglobin concentrations among the groups. Necropsies revealed enlarged yellowish livers in many of the carp-fed mink, especially those fed the 40% carp diet. Liver, spleen, and lung weights of carp-fed mink were significantly greater than those of control mink. Histopathologic examination of the livers revealed various degrees of congestion, hepatocellular fatty changes, and scattered portal lymphocytic infiltration which were most prevalent in mink fed the carp diets. These clinical signs, hematological effects, and histologic alterations are similar to those previously described for chlorinated hydrocarbon toxicoses in mink.

Copyright information

© Springer-Verlag New York Inc. 1995

Authors and Affiliations

  • S. N. Heaton
    • 1
  • S. J. Bursian
    • 1
    • 4
  • J. P. Giesy
    • 2
    • 4
    • 5
  • D. E. Tillitt
    • 6
  • J. A. Render
    • 3
  • P. D. Jones
    • 2
  • D. A. Verbrugge
    • 2
    • 5
  • T. J. Kubiak
    • 7
  • R. J. Aulerich
    • 1
    • 4
  1. 1.Department of Animal ScienceMichigan State UniversityEast LansingUSA
  2. 2.Department of Fisheries and WildlifeMichigan State UniversityEast LansingUSA
  3. 3.Department of PathologyMichigan State UniversityEast LansingUSA
  4. 4.Institute for Environmental ToxicologyMichigan State UniversityEast LansingUSA
  5. 5.Pesticide Research CenterMichigan State UniversityEast LansingUSA
  6. 6.Midwest Science CenterNational Biological SurveyColumbiaUSA
  7. 7.U.S. Fish and Wildlife ServiceEast LansingUSA
  8. 8.Surface Water Quality Division, Michigan Department of Natural ResourcesKnapp CenterLansing
  9. 9.Wellington Science CenterESR EnvironmentalLower HuttNew Zealand
  10. 10.U.S. Fish and Wildlife ServiceDivision of Environmental ContaminantsArlington

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