Immunogenetics

, Volume 33, Issue 1, pp 50–53

Haplotypic polymorphisms of the TNFB gene

Authors

  • Lawrence J. Abraham
    • Department of Clinical ImmunologyRoyal Perth Hospital
  • Daisy Chin Du
    • Department of Clinical ImmunologyRoyal Perth Hospital
  • Kamyar Zahedi
    • Division of Immunology, Children's Hospital , and Department of PediatricsHarvard Medical School
  • Roger L. Dawkins
    • Department of Clinical ImmunologyRoyal Perth Hospital
  • Alexander S. Whitehead
    • Division of Immunology, Children's Hospital , and Department of PediatricsHarvard Medical School
Original Articles

DOI: 10.1007/BF00211695

Cite this article as:
Abraham, L.J., Du, D.C., Zahedi, K. et al. Immunogenetics (1991) 33: 50. doi:10.1007/BF00211695

Abstract

The NTFB genes from two major histocomptibility complex (MHC) ancestral haplotypes have been compared. The genes carried by the ancestral haplotypes 8.1 (A1,B8,BfS,C4AQ0, C4B1,DR3) and 57.1 (A1,B57, BfS,C4A6,C4B1,DR7) were cloned and sequenced to determine the degree of polymorphism. In this report we show that the r e spective TNF genes are allelic and have unique nucleotide sequences. The data demonstrate the presence of three nucleotide differences between the TNFB alleles of 8.1 and 57.1. Two of the differences occur in untranslated regions of the gene but the third nucleotide change results in amino acid differences in the mature TNFB protein. These polymorphisms may have implications with respect to differential regulation in disease-and nondisease-associated haplotypes.

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Copyright information

© Springer-Verlag 1991