Human Genetics

, Volume 96, Issue 6, pp 726–730

Inheritance of migraine investigated by complex segregation analysis


  • Michael Bjørn Russell
    • Department of NeurologyGlostrup Hospital, University of Copenhagen
    • The Glostrup Population Studies, Department of Internal Medicine CGlostrup Hospital, University of Copenhagen
  • Lennart Iselius
    • Department of SurgeryKarolinska Hospital
  • Jes Olesen
    • Department of NeurologyGlostrup Hospital, University of Copenhagen
Original Investigation

DOI: 10.1007/BF00210307

Cite this article as:
Russell, M.B., Iselius, L. & Olesen, J. Hum Genet (1995) 96: 726. doi:10.1007/BF00210307


Migraine is the most common neurological disorder, affecting about 20% of adults. The mode of inheritance was analyzed in the two main types of migraine, migraine without aura (MO) and migraine with aura (MA), by complex segregation analysis using the computer program POINTER. We included 126 probands with MO and 127 probands with MA from the general population. Firstdegree relatives and spouses were blindly interviewed by a neurological research fellow. The complex segregation analysis indicated that both MO and MA have multifactorial inheritance without generational difference.

Copyright information

© Springer-Verlag 1995