Original Investigations

Human Genetics

, Volume 84, Issue 2, pp 185-187

First online:

Monocyte-derived neutrophil chemotactic factor (MDNCF/IL-8) resides in a gene cluster along with several other members of the platelet factor 4 gene superfamily

  • William S. ModiAffiliated withBiological Carcinogenesis and Development Program, Program Resources, Inc., National Cancer Institute, Frederick Cancer Research Facility
  • , Michael DeanAffiliated withBiological Carcinogenesis and Development Program, Program Resources, Inc., National Cancer Institute, Frederick Cancer Research Facility
  • , Hector N. SeuanezAffiliated withLaboratory of Viral Carcinogenesis, National Cancer Institute
  • , Naofumi MukaidaAffiliated withLaboratory of Molecular Immunoregulation, National Cancer Institute
  • , Kouji MatsushimaAffiliated withLaboratory of Viral Carcinogenesis, National Cancer Institute
  • , Stephen J. O'BrienAffiliated withLaboratory of Viral Carcinogenesis, National Cancer Institute

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Summary

Monocyte-derived neutrophil chemotactic factor (MDNCF/IL-8, suggested gene symbol IL8) is a cytokine that chemoattracts and activates neutrophils. Using a panel of human-rodent cell hybrids that preferentially segregate human chromosomes and in situ hybridization, the MDNCF/IL-8 gene was placed on the human gene map at position 4q12-q21. This is the same location where at least three other members (platelet factor 4, melanoma growth stimulatory activity, and interferon-γ induced factor) of the platelet factor 4 gene superfamily reside. In addition, a restriction fragment length polymorphism was identified using MDNCF as a probe in screening genomic DNA digested with HindIII from unrelated individuals.