Journal of Molecular Medicine

, Volume 74, Issue 9, pp 523–526

Microdialysis: a way to study in vivo release of neurotrophic bioactivity: a critical summary

  • C. Humpel
  • T. Ebendal
  • L. Olson

DOI: 10.1007/BF00204978

Cite this article as:
Humpel, C., Ebendal, T. & Olson, L. J Mol Med (1996) 74: 523. doi:10.1007/BF00204978


Microdialysis has been proven to be a valuable tool to study in vivo release of various neurotransmitters in the rat brain. Recently we demonstrated for the first time the release of neurotrophic bioactivity in the brains of awake rats. Neurotrophic factors, however, exist in extremely low concentrations in the brain compared to neurotransmitters, rendering their detection particularly difficult. This review summarizes knowledge about the use of microdialysis for the detection of neurotrophic bioactivity, its limits, and its problems.

Key words

In vivoMicrodialysisReleaseSecretionTrophic factors



Brain-derived neurotrophic factor


Enzyme immunoassay


Nerve growth factor



Copyright information

© Springer-Verlag 1996

Authors and Affiliations

  • C. Humpel
    • 1
  • T. Ebendal
    • 2
  • L. Olson
    • 3
  1. 1.Neurochemistry Unit, Department of PsychiatryInnsbruckAustria
  2. 2.Department of Developmental NeurosciencesUniversity of UppsalaSweden
  3. 3.Department of NeuroscienceKarolinska InstituteStockholmSweden