Journal of Molecular Medicine

, Volume 74, Issue 9, pp 505–513

Hepatocyte growth factor/scatter factor—Met signaling in tumorigenicity and invasion/metastasis

  • Michael Jeffers
  • Sing Rong
  • George F. Vande Woude
Reviews

DOI: 10.1007/BF00204976

Cite this article as:
Jeffers, M., Rong, S. & Vande Woude, G.F. J Mol Med (1996) 74: 505. doi:10.1007/BF00204976

Abstract

Hepatocyte growth factor/scatter factor (HGF/SF) is a pleiotropic effector of cells expressing the Met tyrosine kinase receptor. While HGF/SF-Met signaling clearly plays a role in a variety of normal cellular processes, this signaling pathway has also been implicated in the generation and metastatic spread of tumors. This review discusses in detail several model systems that have been developed to investigate the role of HGF/SF-Met signaling in malignancy and describes additional data regarding the expression of these molecules in human tumors. Collectively the findings support a role for this receptor-ligand pair in human malignancy.

Key words

Hepatocyte growth factor/scatter factorMetTumorigenicityInvasionMetastasis

Abbreviations

ECM/BM

Extracellular matrix/basement membrane

HGF/SF

Hepatocyte growth factor/scatter factor

uPA

Urokinase-type plasminogen activator

uPAR

Urokinase-type plasminogen activator receptor

Copyright information

© Springer-Verlag 1996

Authors and Affiliations

  • Michael Jeffers
    • 1
  • Sing Rong
    • 1
  • George F. Vande Woude
    • 1
  1. 1.ABL-Basic Research ProgramNCI-Frederick Cancer Research and Development CenterFrederickUSA
  2. 2.Central Research Division, Pfizer, Inc.GrotonUSA