Human Genetics

, Volume 87, Issue 3, pp 367–368

Human platelet basic protein/connective tissue activating peptide-III maps in a gene cluster on chromosome 4q12–q13 along with other genes of the β-thromboglobulin superfamily

  • R. H. Wenger
  • H. Hameister
  • K. J. Clemetson
Short Communications

DOI: 10.1007/BF00200921

Cite this article as:
Wenger, R.H., Hameister, H. & Clemetson, K.J. Hum Genet (1991) 87: 367. doi:10.1007/BF00200921

Summary

Pro-platelet basic protein (pro-PBP) is the precursor of the two platelet α-granule proteins, PBP and connective tissue activating peptide-III. Upon platelet activations they are released and further processed in plasma to β-thromboglobulin and neutrophil-activating peptide-2. The gene encoding pro-PBP is mapped in this study to chromosome 4q12–q13. At least four other members of this family of small inducible cytokines, including NAP-1/Il-8 and platelet factor 4, reside within the same locus, indicating a gene cluster for the β-thromboglobulin family.

Copyright information

© Springer-Verlag 1991

Authors and Affiliations

  • R. H. Wenger
    • 1
  • H. Hameister
    • 2
  • K. J. Clemetson
    • 1
  1. 1.Theodor-Kocher-Institut der UniversitätBernSwitzerland
  2. 2.Abteilung Klinische Genetik der UniversitätUlmGermany
  3. 3.Max-Planck-Institut für ImmunobiologieFreiburg i.Br.Germany