Human platelet basic protein/connective tissue activating peptide-III maps in a gene cluster on chromosome 4q12–q13 along with other genes of the β-thromboglobulin superfamily
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- Wenger, R.H., Hameister, H. & Clemetson, K.J. Hum Genet (1991) 87: 367. doi:10.1007/BF00200921
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Pro-platelet basic protein (pro-PBP) is the precursor of the two platelet α-granule proteins, PBP and connective tissue activating peptide-III. Upon platelet activations they are released and further processed in plasma to β-thromboglobulin and neutrophil-activating peptide-2. The gene encoding pro-PBP is mapped in this study to chromosome 4q12–q13. At least four other members of this family of small inducible cytokines, including NAP-1/Il-8 and platelet factor 4, reside within the same locus, indicating a gene cluster for the β-thromboglobulin family.