Human Genetics

, Volume 87, Issue 3, pp 325–327

Assignment of the gene coding for human cytochrome c oxidase subunit VIb to chromosome 19, band q13.1, by fluorescence in situ hybridisation

  • Jan-Willem Taanman
  • Anneke Y. van der Veen
  • Cobi Schrage
  • Hans de Vries
  • Charles H. C. M. Buys
Original Investigations

DOI: 10.1007/BF00200913

Cite this article as:
Taanman, JW., van der Veen, A.Y., Schrage, C. et al. Hum Genet (1991) 87: 325. doi:10.1007/BF00200913

Summary

A cloned, 40 kb, genomic DNA fragment, containing the last exon of the gene for human cytochrome c oxidase subunit VIb and its flanking sequences, was used as a probe to localize the subunit VIb gene on human metaphase chromosomes. The probe was labelled with Bio-11-dUTP and detected by fluorescence. Subsequent R-banding indicated that the cytochrome c oxidase subunit VIb gene is localized in band 19q13.1, extending the evidence that the human nuclear genes of cytochrome c oxidase are not clustered.

Copyright information

© Springer-Verlag 1991

Authors and Affiliations

  • Jan-Willem Taanman
    • 1
  • Anneke Y. van der Veen
    • 2
  • Cobi Schrage
    • 1
  • Hans de Vries
    • 1
  • Charles H. C. M. Buys
    • 2
  1. 1.Laboratory of Physiological Chemistry, University of GroningenKZ GroningenThe Netherlands
  2. 2.Department of Medical GeneticsUniversity of GroningenAW GroningenThe Netherlands