Human Genetics

, Volume 88, Issue 3, pp 344–346

Distribution of ADH2 and ALDH2 genotypes in different populations

  • H. W. Goedde
  • D. P. Agarwal
  • G. Fritze
  • D. Meier-Tackmann
  • S. Singh
  • G. Beckmann
  • K. Bhatia
  • L. Z. Chen
  • B. Fang
  • R. Lisker
  • Y. K. Paik
  • F. Rothhammer
  • N. Saha
  • B. Segal
  • L. M. Srivastava
  • A. Czeizel
Short Communications

DOI: 10.1007/BF00197271

Cite this article as:
Goedde, H.W., Agarwal, D.P., Fritze, G. et al. Hum Genet (1992) 88: 344. doi:10.1007/BF00197271

Summary

The distribution of the human liver alcohol dehydrogenase, ADH2, and aldehyde dehydrogenase, ALDH2, genotypes in 21 different populations comprising Mongoloids, Caucasoids, and Negroids was determined by hybridization of the amplified genomic DNA with allele-specific oligonucleotide probes. Whereas the frequency of the ADH12allele was found to be relatively high in the Caucasoids, Mexican Mestizos, Brazilian Indios, Swedish Lapps, Papua New Guineans and Negroids, the frequency of the ADH22gene was considerably higher in the Mongoloids and Australian Aborigines. The atypical ALDH2 gene (ALDH22) was found to be extremely rare in Caucasoids, Negroids, Papua New Guineans, Australian Aborigines and Aurocanians (South Chile). In contrast, this mutant gene was found to be widely prevalent among the Mongoloids. Individuals possessing the abnormal ALDH2 gene show alcohol-related sensitivity responses (e.g. facial flushing), have the tendency not to be habitual drinkers, and apparently suffer less from alcoholism and alcohol-related liver disease.

Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • H. W. Goedde
    • 1
  • D. P. Agarwal
    • 1
  • G. Fritze
    • 1
  • D. Meier-Tackmann
    • 1
  • S. Singh
    • 1
  • G. Beckmann
    • 2
  • K. Bhatia
    • 3
  • L. Z. Chen
    • 4
  • B. Fang
    • 5
  • R. Lisker
    • 6
  • Y. K. Paik
    • 7
  • F. Rothhammer
    • 8
  • N. Saha
    • 9
  • B. Segal
    • 10
  • L. M. Srivastava
    • 11
  • A. Czeizel
    • 12
  1. 1.Institut für Humangenetik der UniversitätUniversität HamburgHamburg 54Germany
  2. 2.Department of Medical GeneticsUniversity of UmeaUmeaSweden
  3. 3.Papua New Guinea Institute of Medical ResearchGorokaPapua, New Guinea
  4. 4.Cytogenetics UnitAdelaide Children's HospitalNorth Adelaide
  5. 5.Institute of Basic Medical SciencesPekingChina
  6. 6.Department of GeneticsNational Institute of NutritionMexico CityMexico
  7. 7.Department of GeneticsHanyang University School of MedicineSeoulSouth Korea
  8. 8.Department of GeneticsUniversity of ChileSantiagoChile
  9. 9.Division of Human Genetics, Department of PediatricsNational University HospitalSingapore
  10. 10.School of Health SciencesUniversity of AlaskaAnchorageUSA
  11. 11.Department of BiochemistryAll India Institute of Medical SciencesNew DelhiIndia
  12. 12.Department of Human GeneticsNational Institute of HygieneBudapestHungary