Human Genetics

, Volume 88, Issue 3, pp 344–346

Distribution of ADH2 and ALDH2 genotypes in different populations


  • H. W. Goedde
    • Institut für Humangenetik der UniversitätUniversität Hamburg
  • D. P. Agarwal
    • Institut für Humangenetik der UniversitätUniversität Hamburg
  • G. Fritze
    • Institut für Humangenetik der UniversitätUniversität Hamburg
  • D. Meier-Tackmann
    • Institut für Humangenetik der UniversitätUniversität Hamburg
  • S. Singh
    • Institut für Humangenetik der UniversitätUniversität Hamburg
  • G. Beckmann
    • Department of Medical GeneticsUniversity of Umea
  • K. Bhatia
    • Papua New Guinea Institute of Medical Research
  • L. Z. Chen
    • Cytogenetics UnitAdelaide Children's Hospital
  • B. Fang
    • Institute of Basic Medical Sciences
  • R. Lisker
    • Department of GeneticsNational Institute of Nutrition
  • Y. K. Paik
    • Department of GeneticsHanyang University School of Medicine
  • F. Rothhammer
    • Department of GeneticsUniversity of Chile
  • N. Saha
    • Division of Human Genetics, Department of PediatricsNational University Hospital
  • B. Segal
    • School of Health SciencesUniversity of Alaska
  • L. M. Srivastava
    • Department of BiochemistryAll India Institute of Medical Sciences
  • A. Czeizel
    • Department of Human GeneticsNational Institute of Hygiene
Short Communications

DOI: 10.1007/BF00197271

Cite this article as:
Goedde, H.W., Agarwal, D.P., Fritze, G. et al. Hum Genet (1992) 88: 344. doi:10.1007/BF00197271


The distribution of the human liver alcohol dehydrogenase, ADH2, and aldehyde dehydrogenase, ALDH2, genotypes in 21 different populations comprising Mongoloids, Caucasoids, and Negroids was determined by hybridization of the amplified genomic DNA with allele-specific oligonucleotide probes. Whereas the frequency of the ADH12allele was found to be relatively high in the Caucasoids, Mexican Mestizos, Brazilian Indios, Swedish Lapps, Papua New Guineans and Negroids, the frequency of the ADH22gene was considerably higher in the Mongoloids and Australian Aborigines. The atypical ALDH2 gene (ALDH22) was found to be extremely rare in Caucasoids, Negroids, Papua New Guineans, Australian Aborigines and Aurocanians (South Chile). In contrast, this mutant gene was found to be widely prevalent among the Mongoloids. Individuals possessing the abnormal ALDH2 gene show alcohol-related sensitivity responses (e.g. facial flushing), have the tendency not to be habitual drinkers, and apparently suffer less from alcoholism and alcohol-related liver disease.

Copyright information

© Springer-Verlag 1992