Original Articles

Virchows Archiv

, Volume 429, Issue 1, pp 37-42

Losses at 3p common deletion sites in subtypes of kidney tumours: histopathological correlations

  • Piotr HadaczekAffiliated withDepartment of Genetics and Pathology, Pomeranian Medical Academy
  • , Jacek PodolskiAffiliated withDepartment of Genetics and Pathology, Pomeranian Medical Academy
  • , Aleksandra ToloczkoAffiliated withDepartment of Genetics and Pathology, Pomeranian Medical Academy
  • , Grzegorz KurzawskiAffiliated withDepartment of Genetics and Pathology, Pomeranian Medical Academy
  • , Jan LubinskiAffiliated withDepartment of Genetics and Pathology, Pomeranian Medical Academy
  • , Andrzej SikorskiAffiliated withDepartment of Urology, Pomeranian Medical Academy
  • , Pamela RabbittsAffiliated withMRC Clinical Oncology and Radiotherapeutics Unit, Medical Research Council Centre
  • , Kay HuebnerAffiliated withJefferson Cancer Institute, Jefferson Medical College

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Abstract

Deletions of the short arm of chromosome 3 (3p) have been recognized as characteristic features of clear cell renal cell carcinomas (clear cell RCC). We analysed 55 clear-cell RCCs and 30 non-clear-cell kidney tumours (10 papillary and 7 chromophobic RCCs, 11 oncocytomas and 2 collecting duct carcinomas) in loss of heterozygosity (LOH) studies using microsatellite markers for previously observed regions of common deletions on 3p in kidney tumours (3p25, 3p21.3, 3p14.2 and 3p12-13). Alterations were found in all 55 cases of clear-cell RCCs at two to four of the 3p regions. Extensive losses were not found in non-clear-cell tumours except for collecting duct carcinomas; 1 of 10 papillary RCCs showed interstitial deletion limited to a single 3p21.3 locus. LOH analyses using microsatellite markers for regions of common deletions at 3p may be of value in differential diagnosis of kidney tumours.

Key words

Kidney tumour classification 3p Loss of heterozygosity