Virchows Archiv

, Volume 429, Issue 1, pp 37–42

Losses at 3p common deletion sites in subtypes of kidney tumours: histopathological correlations

  • Piotr Hadaczek
  • Jacek Podolski
  • Aleksandra Toloczko
  • Grzegorz Kurzawski
  • Jan Lubinski
  • Andrzej Sikorski
  • Pamela Rabbitts
  • Kay Huebner
Original Articles

DOI: 10.1007/BF00196818

Cite this article as:
Hadaczek, P., Podolski, J., Toloczko, A. et al. Vichows Archiv A Pathol Anat (1996) 429: 37. doi:10.1007/BF00196818

Abstract

Deletions of the short arm of chromosome 3 (3p) have been recognized as characteristic features of clear cell renal cell carcinomas (clear cell RCC). We analysed 55 clear-cell RCCs and 30 non-clear-cell kidney tumours (10 papillary and 7 chromophobic RCCs, 11 oncocytomas and 2 collecting duct carcinomas) in loss of heterozygosity (LOH) studies using microsatellite markers for previously observed regions of common deletions on 3p in kidney tumours (3p25, 3p21.3, 3p14.2 and 3p12-13). Alterations were found in all 55 cases of clear-cell RCCs at two to four of the 3p regions. Extensive losses were not found in non-clear-cell tumours except for collecting duct carcinomas; 1 of 10 papillary RCCs showed interstitial deletion limited to a single 3p21.3 locus. LOH analyses using microsatellite markers for regions of common deletions at 3p may be of value in differential diagnosis of kidney tumours.

Key words

Kidney tumour classification3pLoss of heterozygosity

Copyright information

© Springer-Verlag 1996

Authors and Affiliations

  • Piotr Hadaczek
    • 1
  • Jacek Podolski
    • 1
  • Aleksandra Toloczko
    • 1
  • Grzegorz Kurzawski
    • 1
  • Jan Lubinski
    • 1
  • Andrzej Sikorski
    • 2
  • Pamela Rabbitts
    • 3
  • Kay Huebner
    • 4
  1. 1.Department of Genetics and PathologyPomeranian Medical AcademySzczecinPoland
  2. 2.Department of UrologyPomeranian Medical AcademySzczecinPoland
  3. 3.MRC Clinical Oncology and Radiotherapeutics UnitMedical Research Council CentreCambridgeUK
  4. 4.Jefferson Cancer InstituteJefferson Medical CollegePhiladelphiaUSA