European Journal of Clinical Pharmacology

, Volume 46, Issue 6, pp 523–526

Smoking and body weight influence the clearance of chlorpromazine


  • M. Chetty
    • Drug Studies UnitUniversity of Durban-Westville
  • R. Miller
    • Drug Studies UnitUniversity of Durban-Westville
  • S. V. Moodley
    • Fort Napier Hospital

DOI: 10.1007/BF00196109

Cite this article as:
Chetty, M., Miller, R. & Moodley, S.V. Eur J Clin Pharmacol (1994) 46: 523. doi:10.1007/BF00196109


The population pharmacokinetic parameters of chlorpromazine (CPZ) in chronic schizophrenic patients were evaluated using 189 plasma concentration measurements from 31 patients.

A NONMEM analysis demonstrated that the clearance of CPZ depended on the patient's body weight. Cigarette smoking and cannabis smoking increased the clearance of CPZ. Chronic alcohol consumption and the concurrent use of anticholinergics did not appear to influence the clearance of CPZ significantly.

Key words

ChlorpromazineSchizophrenic patientspopulation pharmacokineticsclearancecigarette smokingcannabis smoking
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© Springer-Verlag 1994