European Journal of Clinical Pharmacology

, Volume 46, Issue 6, pp 523-526

First online:

Smoking and body weight influence the clearance of chlorpromazine

  • M. ChettyAffiliated withDrug Studies Unit, University of Durban-Westville
  • , R. MillerAffiliated withDrug Studies Unit, University of Durban-Westville
  • , S. V. MoodleyAffiliated withFort Napier Hospital

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The population pharmacokinetic parameters of chlorpromazine (CPZ) in chronic schizophrenic patients were evaluated using 189 plasma concentration measurements from 31 patients.

A NONMEM analysis demonstrated that the clearance of CPZ depended on the patient's body weight. Cigarette smoking and cannabis smoking increased the clearance of CPZ. Chronic alcohol consumption and the concurrent use of anticholinergics did not appear to influence the clearance of CPZ significantly.

Key words

Chlorpromazine Schizophrenic patients population pharmacokinetics clearance cigarette smoking cannabis smoking