Human Genetics

, Volume 84, Issue 5, pp 391–395

Localization of the human HF.10 finger gene on a chromosome region (3p21–22) frequently deleted in human cancers

  • Emilio Donti
  • Luisa Lanfrancone
  • Kay Huebner
  • Anna Pascucci
  • Giovanna Venti
  • Gina Pengue
  • Fausto Grignani
  • Carlo M. Croce
  • Luigi Lania
  • Pier Giuseppe Pelicci
Original Investigations

DOI: 10.1007/BF00195806

Cite this article as:
Donti, E., Lanfrancone, L., Huebner, K. et al. Hum Genet (1990) 84: 391. doi:10.1007/BF00195806

Summary

The finger motif is a tandemly repeated DNA-binding domain recently identified in the primary structure of several eukaryotic transcriptional regulatory proteins. It has been proposed that some members of the finger-gene family are implicated in both normal cell proliferation and differentiation. We isolated several human finger genes by means of hybridization with a finger motif-containing DNA probe. One of these finger genes, HF.10, is expressed at low levels in a variety of human tissues and is down-regulated during the in vitro terminal differentiation of human leukemic myeloid cell lines. By in situ hybridization experiments and analysis of interspecific somatic cell hybrids we mapped the HF.10 gene to 3p21–22, a chromosome region frequently involved in karyotypic rearrangements associated with lung and renal cancer.

Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • Emilio Donti
    • 1
  • Luisa Lanfrancone
    • 1
  • Kay Huebner
    • 2
  • Anna Pascucci
    • 3
  • Giovanna Venti
    • 1
  • Gina Pengue
    • 3
  • Fausto Grignani
    • 1
  • Carlo M. Croce
    • 2
  • Luigi Lania
    • 3
  • Pier Giuseppe Pelicci
    • 1
  1. 1.Istituto di Clinica Medica I, Policlinico Monteluce, Università di PerugiaPerugiaItaly
  2. 2.Fels Institute for Cancer Research and Molecular Biology, Temple University School of MedicinePhiladelphiaUSA
  3. 3.Dipartimento di Genetica, Università di NapoliNaplesItaly