CardioVascular and Interventional Radiology

, Volume 17, Issue 2, pp 70–75

Transcatheter arterial embolization followed by percutaneous ethanol injection in the treatment of hepatocellular carcinoma

Authors

  • Riccardo Lencioni
    • Department of RadiologyUniversity of Pisa
  • Claudio Vignali
    • Department of RadiologyUniversity of Pisa
  • Davide Caramella
    • Department of RadiologyUniversity of Pisa
  • Roberto Cioni
    • Department of RadiologyUniversity of Pisa
  • Salvatore Mazzeo
    • Department of RadiologyUniversity of Pisa
  • Carlo Bartolozzi
    • Department of RadiologyUniversity of Pisa
Clinical Investigations

DOI: 10.1007/BF00193920

Cite this article as:
Lencioni, R., Vignali, C., Caramella, D. et al. Cardiovasc Intervent Radiol (1994) 17: 70. doi:10.1007/BF00193920

Abstract

Purpose

The aim of this study was to evaluate the effectiveness of transcatheter arterial embolization (TAE) followed by percutaneous ethanol injection (PEI) in the treatment of large hepatocellular carcinoma (HCC) lesions.

Methods

Fifteen patients with HCC were treated by means of TAE followed by 6–16 ethanol injections. In 10 patients, the HCC was solitary (3–8 cm); 3 patients had 1, and 2 patients had 2 daughter nodules (3 cm or smaller) in addition. In 12 of 15 main tumors and in 4 of 7 daughter nodules, a tumor capsule was observed by computed tomography or magnetic resonance imaging.

Results

Combined treatment with TAE and PEI resulted in complete necrosis of 12 of 15 main tumors and 7 of 7 daughter nodules on biopsy. Treatment failure (incomplete necrosis) occurred in 3 unencapsulated main tumors. The 1-year survival rate in 10 patients was 100%.

Conclusion

The combination of TAE and PEI proved to be an effective treatment for large HCC, including those with 1–2 small daughter nodules. The presence of a tumor capsule significantly correlates (p < 0.05) with a favorable outcome of treatment.

Key words

Liverinterventional procedureLiver neoplasms, therapyComputed tomographyMagnetic resonance imaging
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© Springer-Verlag 1994