Pharmacodynamics

European Journal of Clinical Pharmacology

, Volume 48, Issue 2, pp 123-125

First online:

Randomised crossover comparison of adrenal suppressive effects of dermal creams containing glucocorticosteroids

  • H. W. VisscherAffiliated withPharma Bio-Research International B.V.
  • , J. T. EbelsAffiliated withPharma Bio-Research International B.V.
  • , J. G. H. JonkmanAffiliated withPharma Bio-Research International B.V.
  • , G. A. RodersAffiliated withYamanouchi Europe B.V.

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Abstract

To compare the effect of multiple dose treatment with fatty cream 0.1% hydrocortisone-17-butyrate (LLFC) and fatty cream 0.1% mometasone furoate (EFC), under occlusion on adrenal function, we performed an open label, randomised, two-period crossover study, lasting 30 days, in 12 healthy, male volunteers (age 18–45 y). Morning plasma cortisol and ACTH concentrations were determined before, during, and after the treatments, and a Synacthen test was performed before and during the treatments. Both agents suppressed plasma cortisol concentrations, EFC significantly more than LLFC. ACTH concentrations were normal and were comparable between the two treatments throughout the studies, while the Synacthen tests showed normal rises in cortisol levels. Both treatments were well tolerated. We conclude that EFC has a stronger suppressive effect on plasma cortisol values than LLFC, although for short duration treatments both suppressive effects are transient.

Key words

Hydrocortisone-17-butyrate Mometasone furoate plasma cortisol ACTH concentration Synacthen test healthy volunteers adrenal suppression fatty cream