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Effects of lisinopril on congestive heart failure in normotensive patients with diastolic dysfunction but intact systolic function

  • Pharmacodynamics
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Abstract

This study examined the effects of lisinopril on diastolic function in 12 normotensive patients (mean age 72 years) with symptomatic congestive heart failure, intact left ventricular systolic function and abnormal diastolic function secondary to ischaemic heart disease in a placebo-controlled double blind crossover study, with each treatment dosed orally for 5 continuous weeks. Compared to placebo, lisinopril significantly decreased blood pressure, increased plasma renin activity without altering heart rate or plasma norepinephrine. There was no statistically significant improvement with lisinopril in radionuclide derived peak filling rate and time to peak filling rate, in Doppler echocardiographic measurements of the ratio of peak flow velocity in early diastole to the peak flow velocity of atrial contraction (E:A ratio) and in visual analogue scales of symptoms.

Thus, although angiotension converting enzyme inhibitors may have an established role in the treatment of heart failure secondary to left ventricular systolic dysfunction, its use in patients with isolated diastolic dysfunction remains unclear.

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Authors and Affiliations

  1. Department of Clinical Pharmacology, Ninewells Hospital and Medical School, DD1 9SY, Dundee, UK

    C. C. Lang, A. R. Rahman, B. J. Lipworth & A. D. Struthers

  2. Department of Cardiology, Ninewells Hospital and Medical School, DD1 9SY, Dundee, UK

    C. C. Lang & H. M. McAlpine

  3. Department of Medical Physics, Ninewells Hospital and Medical School, DD1 9SY, Dundee, UK

    N. Kennedy

  4. Division of Clinical Pharmacology, Vanderbilt University School of Medicine, 532 Medical Research Building, 37232-6602, Nashville, TN, USA

    C. C. Lang

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  1. C. C. Lang
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  2. A. R. Rahman
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  3. B. J. Lipworth
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  4. A. D. Struthers
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  5. H. M. McAlpine
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  6. N. Kennedy
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Lang, C.C., Rahman, A.R., Lipworth, B.J. et al. Effects of lisinopril on congestive heart failure in normotensive patients with diastolic dysfunction but intact systolic function. Eur J Clin Pharmacol 49, 15–19 (1995). https://doi.org/10.1007/BF00192352

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  • DOI: https://doi.org/10.1007/BF00192352

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