Immunogenetics

, Volume 37, Issue 3, pp 193–198

Isolation of a novel cDNA clone showing marked similarity to ME491/CD63 superfamily

Authors

  • Nobuhiko Emi
    • First Department of Internal MedicineNagoya University School of Medicine
  • Kenjiro Kitaori
    • First Department of Internal MedicineNagoya University School of Medicine
  • Masao Seto
    • Aichi Cancer Center Research Institute
  • Ryuzo Ueda
    • Aichi Cancer Center Research Institute
  • Hidehiko Saito
    • First Department of Internal MedicineNagoya University School of Medicine
  • Toshitada Takahashi
    • Aichi Cancer Center Research Institute
Original Articles

DOI: 10.1007/BF00191884

Cite this article as:
Emi, N., Kitaori, K., Seto, M. et al. Immunogenetics (1993) 37: 193. doi:10.1007/BF00191884

Abstract

A novel cDNA clone, A15, was isolated by the differential screening of a cDNA library of an immature T cell line, HPB-ALL using radioactive cDNA probes from the mRNA of either HPB-ALL or peripheral blood lymphocytes. It hybridized to a single mRNA species of about 2.0 kilobases which is expressed in HPB-ALL cell line, but not in the PBL or a promyelocytic leukemia cell line, HL-60. The A15 gene codes for a protein of 244 amino acids which contains four potential transmembrane domains and four possible N-linked glycosylation sites. A computer-aided comparison showed a marked similarity to several other membrane proteins: CD9, CD37, CD53, TAPA-1, Sm23, CO-029, and ME491/CD63.

Copyright information

© Springer-Verlag 1993