European Journal of Clinical Pharmacology

, Volume 47, Issue 4, pp 331–335

The psychomotor and cognitive effects of a new antihistamine, mizolastine, compared to terfenadine, triprolidine and placebo in healthy volunteers

  • J. S. Kerr
  • I. Hindmarch
  • C. Dunmore
Pharmacodynamics

DOI: 10.1007/BF00191164

Cite this article as:
Kerr, J.S., Hindmarch, I. & Dunmore, C. Eur J Clin Pharmacol (1994) 47: 331. doi:10.1007/BF00191164

Abstract

Eighteen healthy volunteers received mizolastine 5 mg, 15 mg or 45 mg, terfenadine 60 mg, triprolidine 10 mg or placebo in a 6-way crossover, double blind study. Following each dose, subjects performed a series of tests of cognitive function and psychomotor performance at 1, 3, 5, 8 and 24 hours post-dose. The test battery included critical flicker fusion, choice reaction time, tracking, Stroop and Sternberg memory tests and assessment of subjective sedation.

Sedative effects and a concomitant reduction in psychomotor and cognitive function were observed following triprolidine, terfenadine and the highest dose of mizolastine, 45 mg, e.g. triprolidine reduced CFF threshold by 1.5 Hz and increased reaction time by 50 ms, impairments comparable to those caused by blood alcohol concentrations of 50 mg%, the legal limit in many countries. Mizolastine 5 mg did not differ significantly from placebo and at 15 mg differed only at one test point at one time.

It may be concluded that mizolastine (5 mg and 15 mg) is free from disruptive effects on cognitive function and psychomotor performance, in contrast to terfenadine 60 mg, triprolidine 10 mg and mizolastine 45 mg.

Key words

MizolastineTriprolidineTerfenadineantihistaminespsychomotor performancecognitive functionpsychopharmacology

Copyright information

© Springer-Verlag 1994

Authors and Affiliations

  • J. S. Kerr
    • 1
  • I. Hindmarch
    • 1
  • C. Dunmore
    • 2
  1. 1.Human Psychopharmacology Research UnitUniversity of Surrey, Milford HospitalGodalmingUK
  2. 2.Synthélabo Clinical Research DepartmentLondonUK