Pediatric Surgery International

, Volume 11, Issue 2, pp 153–155

Epidural metastasis in chemoresistant Wilms' tumor with perilobar nephroblastomatosis

  • Hidemitsu Kurosawa
  • Hiroyuki Kurumada
  • Emi Haga
  • Kenichi Sugita
  • Mitsuoki Eguchi
  • Toshiharu Furukawa
  • Yuusaku Kurosu
  • Toshio Fujiwara
  • Jun-ichi Hata
Original Articles

DOI: 10.1007/BF00183751

Cite this article as:
Kurosawa, H., Kurumada, H., Haga, E. et al. Pediatr Surg Int (1996) 11: 153. doi:10.1007/BF00183751
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Abstract

An 8-year-old boy with vertebral and epidural metastases was diagnosed with Wilms' tumor associated with perilobar nephroblastomatosis (NB) based on histologic examination. During combined chemotherapy with vincristine, actinomycin D, doxorubicin, and cyclophosphamide (NWTS-3 J protocol), a rapid increase in tumor size was observed. The treatment was replaced with etoposide and carboplatin (JET regimen). A transient response was sustained for 5 months during this chemotherapy. However, regrowth of the tumor was observed and the patient died 11 months after the initial chemotherapy.

Key words

Wilms' tumor Epidural spinal metastasis Nephroblastomatosis Chemotherapy 

Copyright information

© Springer-Verlag 1996

Authors and Affiliations

  • Hidemitsu Kurosawa
    • 1
  • Hiroyuki Kurumada
    • 1
  • Emi Haga
    • 1
  • Kenichi Sugita
    • 1
  • Mitsuoki Eguchi
    • 1
  • Toshiharu Furukawa
    • 1
  • Yuusaku Kurosu
    • 2
  • Toshio Fujiwara
    • 2
  • Jun-ichi Hata
    • 3
  1. 1.The Second Department of PediatricsDokkyo University School of MedicineTochigiJapan
  2. 2.The First Department of SurgeryDokkyo University School of MedicineTochigiJapan
  3. 3.The Department of PathologyKeio University School of MedicineTokyoJapan
  4. 4.Mibu, TochigiJapan

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