Naunyn-Schmiedeberg's Archives of Pharmacology

, Volume 337, Issue 5, pp 588–590

Histamine H3 receptor-mediated inhibition of serotonin release in the rat brain cortex

Authors

  • Eberhard Schlicker
    • Institut für Pharmakologie und Toxikologie der Rheinischen Friedrich-Wilhelms-Universität Bonn
  • Roland Betz
    • Institut für Pharmakologie und Toxikologie der Rheinischen Friedrich-Wilhelms-Universität Bonn
  • Manfred Göthert
    • Institut für Pharmakologie und Toxikologie der Rheinischen Friedrich-Wilhelms-Universität Bonn
Short communication

DOI: 10.1007/BF00182737

Cite this article as:
Schlicker, E., Betz, R. & Göthert, M. Naunyn-Schmiedeberg's Arch Pharmacol (1988) 337: 588. doi:10.1007/BF00182737

Summary

Rat brain cortex slices preincubated with 3H-serotonin were superfused with physiological salt solution (containing citalopram, an inhibitor of serotonin uptake) and the effect of histamine on the electrically (3 Hz) evoked 3H overflow was studied. Histamine decreased the evoked overflow in a concentration-dependent manner. The inhibitory effect of histamine was antagonized by impromidine and burimamide, but was not affected by pheniramine, ranitidine, metitepine and phentolamine. Given alone, impromidine facilitated the evoked overflow, whereas burimamide, pheniramine and ranitidine had no effect. The results suggest that histamine inhibits serotonin release in the rat brain cortex via histamine H3 receptors, which may be located presynaptically.

Key words

Rat brain cortexSerotonin releasePresynapticH3 ReceptorsImpromidineBurimamide

Copyright information

© Springer-Verlag 1988