Graefe's Archive for Clinical and Experimental Ophthalmology

, Volume 233, Issue 7, pp 407–413

Visual acuities and scotomas after 3 weeks' levodopa administration in adult amblyopia

  • Irene Gottlob
  • Sheryl S. Wizov
  • Robert D. Reinecke
Clinical Investigation

DOI: 10.1007/BF00180943

Cite this article as:
Gottlob, I., Wizov, S.S. & Reinecke, R.D. Graefe's Arch Clin Exp Ophthalmol (1995) 233: 407. doi:10.1007/BF00180943

Abstract

Background: Previous studies have shown that both a single dose of levodopa and a 1-week administration of levodopa improve visual functions in adult amblyopic patients. In the present study, we investigated the effect of increased dosage and duration of levodopa on amblyopes' visual functions. • Methods: Visual acuity and visual fields were examined before and after 3 weeks of daily administration of levodopa/carbidopa as well as 1 month and 2 months after completion of drug therapy in a double masked-design. • Results: A significant increase in visual acuities and a decrease in fixation point scotomas were found. Changes were of comparable dimension to those found after 1 week of levodopa administration. Improvement of visual functions persisted 2 months after the levodopa/carbidopa administration was completed. • Conclusion: The present study confirms previous findings of improvement in visual function in amblyopia after levodopa/carbidopa administration. However, increasing the dosage and the duration of levodopa did not enhance the effect in adults.

Copyright information

© Springer-Verlag 1995

Authors and Affiliations

  • Irene Gottlob
    • 1
    • 2
  • Sheryl S. Wizov
    • 1
    • 2
  • Robert D. Reinecke
    • 1
    • 2
  1. 1.Foerderer Eye Movement Center for ChildrenWills Eye HospitalPhiladelphiaUSA
  2. 2.Department of OphthalmologyJefferson Medical College of Thomas Jefferson UniversityPhiladelphia