Psychopharmacology

, Volume 92, Issue 2, pp 262–264

Effects of pimozide on sucrose consumption and preference

  • A. Towell
  • R. Muscat
  • P. Willner
Original Investigations

DOI: 10.1007/BF00177926

Cite this article as:
Towell, A., Muscat, R. & Willner, P. Psychopharmacology (1987) 92: 262. doi:10.1007/BF00177926

Abstract

The effects of pimozide on sucrose intake were examined, in a two-bottle preference test (sucrose versus water), and in single-bottle tests at five different sucrose concentrations. In the two-bottle test, pimozide dose dependently decreased sucrose intake but increased water intake. In the single-bottle test pimozide decreased sucrose intake at low concentrations but had no effect at high concentrations. The results support a role for dopamine in mediating the rewarding effect of sucrose.

Key words

Sucrose preferenceTwo-bottle testPimozideDopamine

Copyright information

© Springer-Verlag 1987

Authors and Affiliations

  • A. Towell
    • 1
  • R. Muscat
    • 1
  • P. Willner
    • 1
  1. 1.Psychology DepartmentCity of London PolytechnicLondonUK