, Volume 3, Issue 1, pp 71-75

Trimetrexate: a new antifol entering clinical trials

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access


Trimetrexate, a 2,4-diaminoquinazoline derivative, is a new antifol recently introduced into clinical trials. It differs from methotrexate principally in its transport (not carrier-mediated), and its intracellular retention (not polyglutamylated). Trimetrexate is active against tumors which are methotrexate-resistant on the basis of impaired transport, and has a broader range of antitumor activity in preclinical models. Animal studies predict toxicity principally to the central nervous system, gastrointestinal tract and bone marrow.