Psychopharmacology

, Volume 92, Issue 4, pp 520–523

Effect of the selective 5-HT3 receptor antagonists ICS 205-930 and MDL 72222 on 5-HTP-induced head shaking and behavioral symptoms induced by 5-methoxy-N,N,dimethyltryptamine in rats: comparison with some other 5-HT receptor antagonists

  • G. T. Shearman
  • L. Tolcsvai
Original Investigations

DOI: 10.1007/BF00176488

Cite this article as:
Shearman, G.T. & Tolcsvai, L. Psychopharmacology (1987) 92: 520. doi:10.1007/BF00176488

Abstract

The effect of the selective 5-HT3 receptor antagonists ICS 205-930 and MDL 72222 on head shaking behavior induced by l-5-HTP and behavioral symptoms induced with 5-methoxy-N,N,-dimethyltryptamine (5-MeODMT) in rats was evaluated. Both drugs dose-dependently reduced l-5-HTP-induced head shaking but were at least 600 times less potent than pirenperone and ketanserin and at least 50 times less potent than methysergide. ICS 205-930 and MDL 72222 were more than 1000 times less potent than pirenperone or methysergide and 100 times less potent than ketanserin in blocking 5-MeODMT-induced forepaw treading and tremor. Since it appears that head shakes induced by l-5-HTP are mediated by 5-HT2 receptors, these data suggest that ICS 205-930 and MDL 72222 do not significantly interact with 5-HT2 receptors in the brain. Furthermore, the data suggest that ICS 205-930 and MDL 72222 lack appreciable antagonistic activity at the 5-HT receptor(s) mediating those behavioral effects induced by 5-MeODMT.

Key words

5-Hydroxytryptophan Head shakes 5-Methoxy-N,N-dimethyltryptamine Forepaw treading Tremor ICS 205-930 MDL 72222 Pirenperone Ketanserin Methysergide 5-HT receptors 

Copyright information

© Springer-Verlag 1987

Authors and Affiliations

  • G. T. Shearman
    • 1
  • L. Tolcsvai
    • 1
  1. 1.Preclinical ResearchSandoz AGBaselSwitzerland
  2. 2.Merck Sharp and Dohme Research LaboratoriesWest PointUSA