Articles

Journal of Molecular Evolution

, Volume 41, Issue 1, pp 54-66

Structure and evolution of teleost mitochondrial control regions

  • Woo-Jai LeeAffiliated withDepartment of Zoology, University of New HampshireCenter for Marine Biology, University of New Hampshire
  • , Janet ConroyAffiliated withDepartment of Zoology, University of New HampshireCenter for Marine Biology, University of New Hampshire
  • , W. Huntting HowellAffiliated withDepartment of Zoology, University of New HampshireCenter for Marine Biology, University of New Hampshire
  • , Thomas D. KocherAffiliated withDepartment of Zoology, University of New HampshireCenter for Marine Biology, University of New Hampshire

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Abstract

We amplified and sequenced the mitochondrial control region from 23 species representing six families of teleost fish. The length of this segment is highly variable among even closely related species due to the presence of tandemly repeated sequences and large insertions. The position of the repetitive sequences suggests that they arise during replication both near the origin of replication and at the site of termination of the D-loop strand. Many of the conserved sequence blocks (CSBs) observed in mammals are also found among fish. In particular, the mammalian CSB-D is present in all of the fish species studied. Study of potential secondary structures of RNAs from the conserved regions provides little insight into the functional constraints on these regions. The variable structure of these control regions suggests that particular care should be taken to identify the most appropriate segment for studies of intraspecific variation.

Key words

Teleost Mitochondrial DNA D-loop Control region Fish Conserved sequence blocks Repetitive sequences