Investigational New Drugs

, Volume 14, Issue 1, pp 69–85

Pharmacologic strategies for the treatment of meningeal malignancy

  • Susan M. Blaney
  • David G. Poplack

DOI: 10.1007/BF00173684

Cite this article as:
Blaney, S.M. & Poplack, D.G. Invest New Drugs (1996) 14: 69. doi:10.1007/BF00173684


There have been significant strides in the treatment and prevention of meningeal cancer, particularly meningeal leukemia, during the past thirty years. These advantages are a direct result of innovative therapeutic approaches specifically designed to overcome the limitations of systemically administered chemotherapy. Such approaches include the administration of intrathecal chemotherapy by intralumbar or intraventricular injection, the administration of very high-dose systemic chemotherapy, and the administration of cranial or craniospinal irradiation. A better understanding of the central nervous system pharmacokinetics of commonly used anticancer agents has also resulted in improvements in the treatment of meningeal cancer. In this article, the clinical pharmacology of the most commonly used intrathecal agents and pharmacologic strategies for the treatment of meningeal cancer will be discussed. In addition, an overview of new agents for intrathecal administration and other novel CNS targeted therapies will be presented.

Key words

intrathecal Ommaya reservoir intraventricular pharmacology meningeal malignancies 

Copyright information

© Kluwer Academic Publishers 1996

Authors and Affiliations

  • Susan M. Blaney
    • 1
  • David G. Poplack
    • 2
  1. 1.Texas Children's Hospital and Baylor College of MedicineHoustonUSA
  2. 2.Department of PediatricsBaylor College of Medicine and Texas Children's Cancer CenterHoustonUSA
  3. 3.Texas Children's Cancer CenterHoustonUSA

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