, Volume 42, Issue 6, pp 501–530

Mouse T-cell receptor variable gene segment families


  • Bernhard Arden
    • Paul-Ehrlich-Institute
  • Stephen P. Clark
    • Amgen Center
  • Dieter Kabelitz
    • Paul-Ehrlich-Institute
  • Tak W. Mak
    • Amgen InstituteOntario Cancer Institute

DOI: 10.1007/BF00172177

Cite this article as:
Arden, B., Clark, S.P., Kabelitz, D. et al. Immunogenetics (1995) 42: 501. doi:10.1007/BF00172177


All mouse T-cell receptor α/δ, β, and γ variable (Tcra/d, b-, and g-V) gene segments were aligned to compare the sequences with one another, to group them into subfamilies, and to derive a name which complies with the standard nomenclature. It was necessary to change the names of some V gene segments because they conflicted with those of other segments. The traditional classification into subfamilies was re-evaluated using a much larger pool of sequences. In the mouse, most V gene segments can be grouped into subfamilies of closely related genes with significantly less similarity between different subfamilies.

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© Springer-Verlag 1995