Journal of Molecular Evolution

, Volume 40, Issue 1, pp 107–113

Frequencies of synonymous substitutions in mammals are gene-specific and correlated with frequencies of nonsynonymous substitutions

Authors

  • Dominique Mouchiroud
    • Laboratoire de Biométrie, Génétique et Biologic des Populations, U.R.A. 243Université Claude Bernard
  • Christian Gautier
    • Laboratoire de Biométrie, Génétique et Biologic des Populations, U.R.A. 243Université Claude Bernard
  • Giorgio Bernardi
    • Laboratoire de Génétique MoléculaireInstitut Jacques Monod
Articles

DOI: 10.1007/BF00166602

Cite this article as:
Mouchiroud, D., Gautier, C. & Bernardi, G. J Mol Evol (1995) 40: 107. doi:10.1007/BF00166602

Abstract

The frequencies of synonymous substitutions of mammalian genes cover a much wider range than previously thought. We report here that the different frequencies found in homologous genes from a given mammalian pair are correlated with those in the same homologous genes from a different mammalian pair. This indicates that the frequencies of synonymous substitutions are gene-specific (as are the frequencies of nonsynonymous substitutions), or, in other words, that “fast” and “slow” genes in one mammal are fast and slow, respectively, in any other one. Moreover, the frequencies of synonymous substitutions are correlated with the frequencies of nonsynonymous substitution in the same genes.

Key words

DNA repairDNA replicationDNA transcriptionIsochores
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Copyright information

© Springer-Verlag New York Inc. 1995