Article

Journal of Neuro-Oncology

, Volume 1, Issue 3, pp 203-209

Brain metastases from colon cancer

  • T. L. CascinoAffiliated withDepartments of Neurology, Memorial Sloan-Kettering Cancer Center and Cornell University Medical College
  • , J. M. LeavengoodAffiliated withDepartments of Neurology, Memorial Sloan-Kettering Cancer Center and Cornell University Medical College
  • , N. KemenyAffiliated withDepartments of Medicine, Memorial Sloan-Kettering Cancer Center and Cornell University Medical College
  • , J. B. PosnerAffiliated withDepartments of Neurology, Memorial Sloan-Kettering Cancer Center and Cornell University Medical College

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Abstract

Between 1977 and 1980 we evaluated 40 patients who developed brain metastases from colon cancer (4% of total patients with colon cancer). The brain metastasis was discovered in only one patient prior to cancer diagnosis; all others had known colon cancer for 2 to 48 months (median 24.5 months) prior to neurologic presentation. The colon tumor was left-sided in 32; 32 had regional lymph node metastases at neurological presentation; 37 patients had extensive systemic metastasis as well as the brain lesion. Median survival from onset of therapy for brain metastasis was 9 weeks in 32 radiation therapy (RT) treated patients (range, 2–57 weeks), 37 weeks in 7 surgically resected patients (2–84 weeks), and 4 weeks (3.5 weeks) in 2 chemotherapy patients. Follow-up CT scans were improved in 2 of 11 radiated patients. Five of 6 surgically treated patients with CT follow-up demonstrated recurrent tumor (median 4 months). The prognosis for patients with brain metastasis in colon cancer is poor, regardless of therapy.

Keywords

brain metastasis brain metastasis colon cancer radiation therapy CT scans