Journal of Neuro-Oncology

, Volume 1, Issue 3, pp 203–209

Brain metastases from colon cancer

  • T. L. Cascino
  • J. M. Leavengood
  • N. Kemeny
  • J. B. Posner
Article

DOI: 10.1007/BF00165604

Cite this article as:
Cascino, T.L., Leavengood, J.M., Kemeny, N. et al. J Neuro-Oncol (1983) 1: 203. doi:10.1007/BF00165604

Abstract

Between 1977 and 1980 we evaluated 40 patients who developed brain metastases from colon cancer (4% of total patients with colon cancer). The brain metastasis was discovered in only one patient prior to cancer diagnosis; all others had known colon cancer for 2 to 48 months (median 24.5 months) prior to neurologic presentation. The colon tumor was left-sided in 32; 32 had regional lymph node metastases at neurological presentation; 37 patients had extensive systemic metastasis as well as the brain lesion. Median survival from onset of therapy for brain metastasis was 9 weeks in 32 radiation therapy (RT) treated patients (range, 2–57 weeks), 37 weeks in 7 surgically resected patients (2–84 weeks), and 4 weeks (3.5 weeks) in 2 chemotherapy patients. Follow-up CT scans were improved in 2 of 11 radiated patients. Five of 6 surgically treated patients with CT follow-up demonstrated recurrent tumor (median 4 months). The prognosis for patients with brain metastasis in colon cancer is poor, regardless of therapy.

Keywords

brainmetastasisbrain metastasiscolon cancerradiation therapyCT scans

Copyright information

© Martinus Nijhoff Publishers 1983

Authors and Affiliations

  • T. L. Cascino
    • 1
  • J. M. Leavengood
    • 1
  • N. Kemeny
    • 2
  • J. B. Posner
    • 1
  1. 1.Departments of NeurologyMemorial Sloan-Kettering Cancer Center and Cornell University Medical CollegeNew YorkUSA
  2. 2.Departments of MedicineMemorial Sloan-Kettering Cancer Center and Cornell University Medical CollegeNew YorkUSA
  3. 3.Mayo ClinicRochesterUSA