, Volume 39, Issue 4, pp 418-430

The posterior probability distribution of alignments and its application to parameter estimation of evolutionary trees and to optimization of multiple alignments

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access

Abstract

How to sample alignments from their posterior probability distribution given two strings is shown. This is extended to sampling alignments of more than two strings. The result is first applied to the estimation of the edges of a given evolutionary tree over several strings. Second, when used in conjunction with simulated annealing, it gives a stochastic search method for an optimal multiple alignment.

Correspondence to: L. Allison