Interaction between alcohol consumption and positivity for antibodies to hepatitis C virus on the risk of liver cirrhosis: A case-control study
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To assess the risk of developing liver cirrhosis associated with alcohol consumption, HBV and HCV infection markers, we carried out a case-control study involving 115 patients admitted to the medical departments of the general hospitals in the province of L'Aquila (Abruzzo, Italy) who received for the first time the diagnosis of liver cirrhosis, and 167 controls randomly selected among patients admitted to the same hospitals as the cases. Alcohol intake was measured in all 282 subjects using an already validated standardized questionnaire, and expressed as mean lifetime daily alcohol intake in grams. The mean lifetime daily alcohol intake showed a dose-dependent effect on the risk of cirrhosis: the relative risk significantly rose to 3.8 (95% CI: 2.0 − 7.3) for a mean daily intake of ≥101 g alcohol; for HBsAg positivity the relative risk of cirrhosis was 23.0 (95% CI: 4.9 − 107.8) and for anti-HCV positivity it was 8.7 (95% CI: 4.3 − 17.6). After applying a multiple logistic regression analysis in a multivariate model including mean lifetime alcohol intake and anti-HCV status, both variables were significantly associated with the risk of cirrhosis (relative risks = 5.3 − 95% CI: 2.3 −12.2 and 9.9 − 95% CI: 4.4 − 22.0, respectively). The combination of these two variables was found to fit an additive - but not multiplicative - model relative to the risk of cirrhosis: furthermore, the interaction of the anti-HCV status with the presence or absence of cirrhosis did not result in a significant source of variability for the mean lifetime daily alcohol intake. We conclude that alcohol intake, HBsAg positivity and anti-HCV positivity are significantly associated with the risk of cirrhosis, but the risk associated with alcohol intake is independent of anti-HCV status.
- Amoroso P., Lettieri G., Guarnaccia D., et al. (dy1990): Prevalence of hepatitis C virus antibodies in chronic liver diseases in Southern Italy. Abstracts of International Symposium on Progress and Prospects in Viral Hepatitis - Bari, February 15–17, p. 96.
- Annoni G., Rumi M.G., Donato M.F., et al. (1990): Hepatitis C virus (HCV) antibodies in alcoholics. Abstracts of the 25th Meeting of the European Association for the Study of the Liver. Budapest, Hungary, October 3–6 - J. of Hepatology, suppl. 2 to vol. 11, S2.
- Breslow N.E. andDay N.E. (eds) (1980): Statistical methods in cancer research. Vol. I, IARC Scientific Publication n° 32- Lyon: International Agency for Research on Cancer.
- Brillanti S.,Barbara L.,Miglioli M. andBonino F. (1989): Hepatitis C virus: a possible cause of chronic hepatitis in alcoholics - Lancetii: 1390–1391.
- Bruix J.,Berrera J.M.,Calvet X.,et al. (1989): Prevalence of antibodies to hepatitis C virus in Spanish patients with hepatocellular carcinoma and hepatic cirrhosis - Lancetii: 1004–1006.
- Chevillotte G.,Durhec J.P.,Gerolami A., et al. (1983): Interaction between hepatitis B virus and alcohol consumption in liver cirrhosis - Gastroenterology85: 141–145.
- Chiaramonte M., Fabris P., Delaito M., et al. (1990): Anti-HCV in alcoholic liver disease — Abstracts of International Symposium on Progress and Prospects in Viral Hepatitis, Bari, February 15–17, p. 97.
- Choo Q.L.,Kuo G.,Weiner A.J.,et al. (1989): Isolation of a cDNA clone derived from a blood borne non-A, non-B viral hepatitis genome - Science244:359–362.
- Colombo M.,Kuo G.,Choo Q.L.,et al.(1989): Prevalence of antibodies to hepatitis C virus in Italian patients with hepatocellular carcinoma -Lancetii: 1006–1008.
- Corrao G.,Aricò S.,Russo R.,Carle F.,et al. (1991): Alcohol consumption and non-cirrhotic chronic hepatitis: a case-control study - Int. J. Epidemiol.20: 1037–1042.
- Corrao G.,Lepore A.R.,Rapone C.,et al. (1991): Riproducibilità di un questionario alcologico per uno studio caso-controllo sulle epatopatie croniche -Epid. e Preven.46: 45–49.
- Editorial (1984): Who gets alcoholic cirrhosis? -Lanceti: 263–264.
- Estaban J.I.,Estaban R.,Viladomin L.,et al. (1989): Hepatitis C virus antibodies among risk group in Spain - Lancetii: 294–297.
- Gargot D.,Ducreux M.,Dussaix E.,et al. (1990): Antibodies to hepatitis C virus in patients with positive HBsAg - Dig. Dis. Sci.35 (11): 1437–1438.
- Giuliani-Piccari G., Formica G., Sarti F., et al. (1990): Prevalence of HCV infection in non-A, non-B chronic liver diseases in Italy - Abstracts of International Symposium on Viral Hepatitis and Liver Disease. Houston, April 4–8, p. 145.
- Giusti G.,Galanti B. andGaeta G.B. (1980): Epidemiology of viral hepatitis in Italy - Boll. Ist. Sieroter. Milan59: 571.
- Gray J.S.,Wreghitt T.G.,Friend P.J.,et al. (1990): Differentiation between specific and non-specific hepatitis C antibodies in chronic liver disease -Lancetii: 609–610.
- Kuo G.,Choo Q.L.,Alter H.J.,et al. (1989): An assay for circulating antibodies to a major etiologic virus of human non-A, non-B hepatitis - Science244: 362–364.
- Mendenhall C.L., Seeff L., Diehl A.M., et al. (1990): Hepatitis B and C serological markers: relationship to alcoholic hepatitis and cirrhosis - Abstracts of International Symposium on Viral Hepatitis and Liver Disease. Houston, April. 4–8, p. 144.
- Mitamura K., Tanaka N., Aikawa T., et al. (1990): Detection of antibodies to hepatitis C virus in patients with various liver disease in Japan —Abstracts of International Symposium on Viral Hepatitis and Liver Disease, Houston, April 4–8, p. 145.
- Nalpas B.,Driss F.,Pol S.,et al. (1991): Association between HCV and HBV infection in hepatocellular carcinoma and alcoholic liver disease - J. of Hepatology12: 70–74.
- Pagliaro L.,Rinaldi F.,Craxì A.,et al. (1983): Percutaneous blind biopsy versus laparoscopy with guided biopsy in diagnosis of cirrhosis - Dig. Dis. Sci.28: 39–43.
- Poynard T., Aubert A., Lazizi Y., et al. (1990): Is HCV associated with cirrhosis in drinkers? — Abstracts of International Symposium on Viral Hepatitis and Liver Disease. Houston, April 4–8, p. 144.
- Realdi G.,Fattovich G.,Alberti A.,et al. (1987): Natural history of cirrhosis of the liver: methods and fields of research - Elsevier Science Publisher, Amsterdam pp. 323–334.
- Rothman K.J. (1976): The estimation of synergy or antagonism - Am. J. Epidemiol.103: 506–511.
- Simonetti R.G.,Cottone M.,Craxi A., et al. (1989): Prevalence of antibodies to hepatitis C virus in hepatocellular carcinoma - Lancetii: 1338.
- Sørensen T.I.A. (1989): Alcohol and liver injury: dose-related or permissive effect? - Liver9: 189–197.
- Van der Poel C.L.,Reesink H.W.,Lelie P.N.,et al. (1989): Anti-hepatitis C antibodies and non-A, non-B post-transfusion hepatitis in the Netherlands - Lancetii: 297–298.
- Villa E.,Baldini G.,DiStabile S.,et al. (1985): Alcohol and hepatitis B virus infection - Acta med. Scand. Suppl.703: 97–101.
- Interaction between alcohol consumption and positivity for antibodies to hepatitis C virus on the risk of liver cirrhosis: A case-control study
European Journal of Epidemiology
Volume 8, Issue 5 , pp 634-639
- Cover Date
- Print ISSN
- Online ISSN
- Kluwer Academic Publishers
- Additional Links
- Liver cirrhosis
- Anti-Hepatitis C virus antibodies
- Hepatitis B virus infection
- Alcohol consumption
- Case-control study
- Unconditional logistic regression interaction
- Industry Sectors
- Author Affiliations
- 1. Department of Internal Medicine and Public Health, Section of Clinical Epidemiology University of L Aquila, Via Verdi, 28, 67100, L Aquila, Italy
- 2. Clinical Analysis Laboratory, Hospital of Tagliacozzo, Abruzzo, Italy
- 3. Division of Gastroenterology, “Mauriziano Umberto I” - Hospital of Turin, Turin, Italy