European Journal of Epidemiology

, Volume 8, Issue 6, pp 789–796

A case-control study of major congenital heart defects in Sweden — 1981–1986

  • P. Pradat
Article

DOI: 10.1007/BF00145321

Cite this article as:
Pradat, P. Eur J Epidemiol (1992) 8: 789. doi:10.1007/BF00145321

Abstract

This paper reports the results of a case-control study of major congenital heart defects (CHD) in Sweden. During the period 1981–1986, 1,324 such cases were identified and 2,648 controls were selected. Some common maternal characteristics and exposures were studied using information from prospectively collected data. Possible associations with CHD were found for previous perinatal death, maternal diabetes, epilepsy, hydramnios and disproportion between fetus and pelvis. More specific associations were observed between previous spontaneous abortion, epilepsy, hydramnios and truncus anomalies and between diabetes and septal anomalies. However, no associations were found with involuntary childlessness, contraceptive use, or smoking.

Key words

Congenital heart defect Case-control study Diabetes Epilepsy Abortion 

Abbreviations

ASD

atrial septal defect

CHD

congenital heart defect

CI

confidence interval

CoA

coarctation of the aorta

DORY

double outlet right ventricle

ECD

endocardial cushion defect

HLHS

hypoplastic left heart syndrome

IUD

intrauterine device

LMP

last menstrual period

OC

oral contraceptive

OR

odds ratio

PDA

patent ductus arteriosus

TGV

transposition of the great vessels

VSD

ventricular septal defect

Copyright information

© Gustav Fischer 1992

Authors and Affiliations

  • P. Pradat
    • 1
  1. 1.Department of EmbryologyUniversity of LundLundSweden

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