HCV transmission in family members of subjects with HCV related chronic liver disease Article Accepted: 10 October 1995 DOI:
Cite this article as: Demelia, L., Vallebona, E., Poma, R. et al. Eur J Epidemiol (1996) 12: 45. doi:10.1007/BF00144427 Abstract
To investigate the risk of sexual and intrafamilial transmission of HCV, 220 family members of 76 patients (index cases) with chronic type C viral liver disease were tested for serological markers of HCV Of the family members, 129 were offspring, 64 sexual partners, 15 parents and 12 siblings of the index cases. Anti-HCV was tested in all the household contacts; HCV-RNA was tested in antibody positive samples. The serologic markers of HCV were tested in a control group of 168 family members of 81 patients with chronic hepatitis unrelated to HCV. The overall prevalence of anti-HCV was 8.2% compared to 0.6% in the control group (
p < 0.001). Sexual partners were anti-HCV positive more frequently than the other contacts (20% vs 2.2%; p < 0.001), without any difference in males or females. No correlation was observed between the occurrence of HCV infection in contacts and age, severity of liver disease or risk factor for the acquisition of HCV in the index cases. Seven of the 18 (39%) anti-HCV positive family contacts had biochemical evidence of chronic liver disease, histologically confirmed in the 6 patients who underwent a liver biopsy. Liver chemistry was normal in all the HCV-negative contacts. Ten of the 18 anti-HCV positive contacts (55%) were HCV-RNA positive. Genotypes were the same (lb) in 4 of the 7 viremic couples of subjects: in 3 of the 6 couples of sexual partners and in the only mother/son couple. These data suggest the occurrence of intraspousal transmission of HCV, while intrafamiliar acquisition of HCV in non-sexual contacts seems to be rare. Key words HCV HCV sexual transmission HCV intrafamilial transmission Spread of HCV Epidemiology of HCV References
Alter MJ, Coleman PJ, Alexander WJ, et al. Importance of heterosexual activity in the trasmission of hepatitis B and non-A non-B hepatitis. JAMA 1989; 262: 1201–1205.
Kiyosawa K, Gibi Y, Sodeyama T, et al. Possible infections causes in 651 patients with acute viral hepatitis during a 10 years period (1976–1985). Liver 1987; 7: 163–168.
Akahane Y, Aikawa T, Sugai Y, et al. Transmission of HCV between spouses. Lancet 1992; 339: 1059.
Bresters D, Mauser-Bunschoten EP, Reesink HW, et al. Sexual trasmission of hepatitis C virus. Lancet 1993; 342: 210.
Honda M, Kaneko S, Masashi U, Kobayashi K, Murakami S. Risk of hepatitis C virus infection through household contact with chronic carriers: analysis of nucleotide sequences. Hepatology 1993; 17: 971.
Kiyosawa K, Sodeyama T, Tanaka E, et al. Intrafamilial trasmission of hepatitis C virus in Japan. J Med Virol 1991; 33: 114–116.
Tor J, Llibre JM, Carbonell M, et al. Sexual transmission of hepatitis C virus and its relation with hepatitis B virus and HIV. Br Med J 1990; 301: 1130–1133.
Morris AJ, Rassam SW, Brown D, Dusheiko GM. Detection of HCV RNA in body fluids of patients with chronic hepatitis C infection. Hepatology 1992; 16: 570.
Wang JT, Wang TH, Sheu JC, Lin JT, Chen DS. Hepatitis C virus RNA in saliva of patients with post-transfusion hepatitis and low efficiency of transmission among spouses. J Med Virol 1992; 36: 28.
Fried MW, Shindo M, Fong TL, et al. Absence of hepatitis C viral RNA from saliva and semen of patiens with chronic hepatitis C. Gastroenterology 1992; 102: 1306–1308.
Hsu HH, Wright TL, Luba D, et al. Failure to detect hepatitis C virus genome in human secretions with the polymerase chain reaction. Hepatology 1991; 14: 763–767.
Terada S, Kawanishi K, Katayama K. Minimal hepatitis C infectivity in semen. Ann Intern Med 1992; 117: 171.
13.Degos F, Thiers V, Erlinger S, et al. Neonatal trasmission of HCV from mother with chronic hepatitis. Lancet 1991; 338: 758.
Inoue Y, Miyamura T, Unayama T, Takahashi K, Saito I. Maternal transfer of HCV. Nature 1991; 353: 609.
Roudot-Thoraval F, Pawlotsky JM, Thiers V, et al. Lack of mother-to-infant trasmission of hepatitis C virus in human immunodeficiency virus seronegative women: a prospective study with hepatitis C virus RNA testing. Hepatology 1993; 17, 5: 772–779.
Thaler MM. Park CK, Landers DV, et al. Vertical transmission of hepatitis C virus. Lancet 1991; 338: 17–18.
17.Ohto H, Terazawa S, Sasaki N, et al. Vertical Transmission of Hepatitis C Virus Collaborative Study Group. Transmission of hepatitis C virus from mothers to infants. N Engl J Med 1994; 330: 744–750.
Eyster ME, Alter HJ, Aledort LM, et al. Heterosexual co-trasmission of hepatitis C virus (HCV) and human immunodeficiency virus (HIV). Ann Intern Med 1991; 115: 764–768.
Melbye M, Biggar RJ, Wan Tzin P, Krogsgaard. Sexual transmission of hepatitis C virus: cohort study (1981–1989) among European homosexual men. Br Med J 1990; 301: 210–212.
Riestra S, Suarez A, Rodrigo L. Transmission of hepatitis C virus. Ann Intern Med 1990; 113: 411–412.
Tedder RS, Gilson RJ, Briggs M, et al. Hepatitis C virus: evidence for sexual transmission. Br Med J 1991; 302: 1299–1302.
22.Dény P, Roulot D, Asselot C, et al. Low rate of hepatitis C virus (HCV) transmission within the family. J Hepatology 1992; 14: 409.
Everhart JE, Di Bisceglie AM, Murray LM, et al. Risk for non-A, non-B (type C) hepatitis through sexual or household contact with chronic carriers. Ann Intern Med 1990; 112: 544–545.
24.Garson JA, Tedder RS, Briggs M, et al. Detection of hepatitis C viral sequences in blood donations by “nested” polymerase chain reaction and prediction of infectivity. Lancet 1990; 335: 1419–1422.
Imberti L, Cariani E, Bettinardi A, et al. An immunoassay for specific amplified HCV sequences. J Virol Methods 1991; 34: 233–243.
Mantero G, Zonaro A, Bertolo P, Primi D. DNA enzyme immunoassay (DEIA): a general method for detecting polymerase chain reaction products based on anti-DNA antibody. Clin Chem 1991; 37: 422–429.
Simmonds P, Holmes EC, Cha TA, et al. Classification of hepatitis C virus into six major genotypes and a series of subtypes by phylogenetic analysis of the NS-5 region. J Gen Virol 1993; 74: 2391–2399.
Widell A, Mansson AS, Sundstron G, Hansson BG, Nordenfelt E. Hepatitis C virus RNA in blood donor sera detected by polymerase chain reaction: comparison with supplementary hepatitis C antibody assays. J Med Virol 1991; 35: 253–258.
Viazov S, Zibert A, Ramakrishnan K, et al. Typing of hepatitis C virus isolates by DNA enzyme immunoassay. J Virol Methods 1994; 48: 81–91.
Caporaso N, Morisco F, Romano M, et al. Familial clustering of hepatitis C virus infection and chronic liver disease. Ital J Gastroenterol 1990; 22: 281.
Chang TT, Liou TC, Young KC, et al. Intrafamilial transmission of hepatitis C virus: the important role of inapparent transmission. J Med Virol 1994; 42: 91.
32.Nishiguchi S, Fukuda K, Shiomi S, et al. Familial clustering of HCV. Lancet 1992; 339: 1486.
Jarvis LM, Watson HG, MacOmish F, et al. Frequent reinfection and reactivation of hepatitis C virus genotypes in multitrasfused hemophiliacs. JID 1994; 170: 1018–1022.
Soriano V, Nedjar S, Garcia-Samaniego J, et al. and the hepatitis-HIV Spanish Study Group. J Hepatol. 1995; 22: 598–599.
Kao JH, Chen PG, Lai MY, et al. Mixed infections of hepatitis C virus as a factor in acute exacerbations of chronic type C hepatitis. JID 1994; 170: 1128–1233.
Chayama K, Kobayashi M, Tsubota A, et al. Molecular analysis of intraspousal transmission of hepatitis C virus. J Hepatol 1995; 22: 431–439.
Daikos GL, Lai S, Fischl MA. Hepatitis C virus infection in a sexually active inner city population. The potential for heterosexual transmission. Infection 1994; 22: 72–74.
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