Biotechnology Letters

, Volume 16, Issue 8, pp 831–836

High production of 1,3-propanediol from glycerol by Clostridium butyricum VPI 3266 in a simply controlled fed-batch system

Authors

  • S. Saint-Amans
    • Institut National des Sciences Appliquées, Centre de Bioingénierie Gilbert Durand, URA CNRS 544, L.A.INRA. Complexe Scientifique de Rangueil
  • P. Perlot
    • Institut National des Sciences Appliquées, Centre de Bioingénierie Gilbert Durand, URA CNRS 544, L.A.INRA. Complexe Scientifique de Rangueil
  • G. Goma
    • Institut National des Sciences Appliquées, Centre de Bioingénierie Gilbert Durand, URA CNRS 544, L.A.INRA. Complexe Scientifique de Rangueil
  • P. Soucaille
    • Institut National des Sciences Appliquées, Centre de Bioingénierie Gilbert Durand, URA CNRS 544, L.A.INRA. Complexe Scientifique de Rangueil
Article

DOI: 10.1007/BF00133962

Cite this article as:
Saint-Amans, S., Perlot, P., Goma, G. et al. Biotechnol Lett (1994) 16: 831. doi:10.1007/BF00133962

Summary

A simple fed-batch system which controls substrate feeding by measuring the CO2 produced during the fermentation, was developped. This Fed-batch approach allowed high production of 1,3-propanediol from glycerol by Clostridium butyricum by avoiding substrate inhibition phenomena. 65 g/l of 1,3-propanediol was produced with a productivity of 1.21 g/l.h and a yield of 0.56. The concentration of 1,3-propanediol obtained and the productivity were significantly higher than those reached in batch culture.

Copyright information

© Chapman & Hall 1994