, Volume 15, Issue 10, pp 997-1000

Production of an indolizidine alkaloid, swainsonine by the filamentous fungus, Metarhizium anisopliae

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The physiology of Metarhizium anisopliae has been studied with a view to improving swainsonine production. In preliminary work, the stability of pure swainsonine in aqueous solution has been investigated under varying conditions of pH and temperature and in the presence of oxidizing agents. The effects of oxygen on the growth and morphology of M.anisopliae and the production of swainsonine were also examined. Shaken flask fermentations have been carried out in order to develop a medium suitable for production of swainsonine.