Journal of Computer-Aided Molecular Design

, Volume 10, Issue 4, pp 273–283

Wavelets and molecular structure

Authors

  • Mike Carson
    • Center for Macromolecular CrystallographyUniversity of Alabama at Birmingham
Research Papers

DOI: 10.1007/BF00124497

Cite this article as:
Carson, M. J Computer-Aided Mol Des (1996) 10: 273. doi:10.1007/BF00124497

Summary

The wavelet method offers possibilities for display, editing, and topological comparison of proteins at a user-specified level of detail. Wavelets are a mathematical tool that first found application in signal processing. The multiresolution analysis of a signal via wavelets provides a hierarchical series of ‘best’ lower-resolution approximations. B-spline ribbons model the protein fold, with one control point per residue. Wavelet analysis sets limits on the information required to define the winding of the backbone through space, suggesting a recognizable fold is generated from a number of points equal to 1/4 or less the number of residues. Wavelets applied to surfaces and volumes show promise in structure-based drug design.

Keywords

B-splinesNURBSRibbonsProtein editingProtein foldLow-resolution models
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Copyright information

© ESCOM Science Publishers B.V 1996