Clinical & Experimental Metastasis

, Volume 8, Issue 2, pp 215–224

Enhancement of experimental metastatic ability by tumor necrosis factor-alpha alone or in combination with interferon-gamma

  • P. -L. Lollini
  • C. De Giovanni
  • G. Nicoletti
  • A. Bontadini
  • P. -L. Tazzari
  • L. Landuzzi
  • K. Scotlandi
  • P. Nanni
Article

DOI: 10.1007/BF00117794

Cite this article as:
Lollini, P.L., De Giovanni, C., Nicoletti, G. et al. Clin Exp Metast (1990) 8: 215. doi:10.1007/BF00117794

The effects of recombinant tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma) on B16 mouse melanoma experimental metastatic ability and major histocompatibility complex (H-2b) antigens expression were studied. B16 cells exposed in vitro to TNF-alpha had an increased H-2 expression and were more metastatic than untreated cells. The simultaneous treatment with TNF-alpha and IFN-gamma amplified the enhancement of experimental metastasis and all other effects obtained with TNF-alpha alone. The B16 clone B78H1, selectively resistant to H-2 induction and to enhancement of metastatic ability by IFN-gamma, was not affected by treatment with TNF-alpha and with TNF-alpha + IFN-gamma. These findings contribute to a better understanding of the pleiotropic effects of TNF, some of which can have opposing actions in the complex tumor-host relationships.[/p]

Copyright information

© Taylor & Francis Ltd 1990

Authors and Affiliations

  • P. -L. Lollini
    • 1
    • 2
  • C. De Giovanni
    • 1
  • G. Nicoletti
    • 1
    • 2
  • A. Bontadini
    • 3
  • P. -L. Tazzari
    • 3
  • L. Landuzzi
    • 1
  • K. Scotlandi
    • 1
  • P. Nanni
    • 1
  1. 1.Istituto di CancerologiaUniversiti di BolognaItaly
  2. 2.I.S.T.Sezione Aggregata di BolognaGenova
  3. 3.Istituto di Ematologia ‘L. e A. Seragnoli’Università di BolognaItaly
  4. 4.Istituto di CancerologiaBolognaItaly