Cancer Causes & Control

, Volume 6, Issue 6, pp 545–550

Olive oil, other dietary fats, and the risk of breast cancer (Italy)

  • Carlo La Vecchia
  • Eva Negri
  • Silvia Franceschi
  • Adriano Decarli
  • Attilio Giacosa
  • Loren Lipworth
Research Papers

DOI: 10.1007/BF00054164

Cite this article as:
La Vecchia, C., Negri, E., Franceschi, S. et al. Cancer Causes Control (1995) 6: 545. doi:10.1007/BF00054164

Data from a multicenter case-control study on breast cancer conducted in Italy have been used to analyze the relationship of olive oil and other dietary fats to breast cancer risk. Cases were 2,564 women hospitalized with histologically confirmed, incident breast cancer. Controls were 2,588 women admitted to the same network of hospitals for acute, non-neoplastic, non-hormone related, on-digestive tract disorders. Cases and controls were interviewed between 1991 and 1994 using a validated food-frequency questionnaire. The data were modelled through multiple logistic regression controlling for demographic and reproductive breast-cancer risk factors, energy intake and, mutually, for types of dietary fat. For olive oil, compared with the lowest quintile, the odds ratios (OR) were 1.05, 0.99, 0.93, and 0.87 for increasing quintiles of intake; in a model postulating linear logit increase, the OR per unit (30g) was 0.89 (95 percent confidence interval [CI]=0.81–0.99, P=0.03). Among other oils or fats considered, the OR for the highest level of intake was 0.72 (CI=0.6–0.9) for a group of specific seed oils (including safflower, maize, peanut, and soya) compared with nonusers. The ORs for the highest cf lowest level of intake were 0.80 for mixed or unspecified seed oils, 0.95 for butter, and 0.96 for margarine. The study, based on a large dataset from various Italian regions, shows an inverse relationship of breast cancer risk with intake of olive oil and other vegetable oils, but not with butter or margarine.

Key words

Breast cancer dietary fat females Italy olive oil 

Copyright information

© Rapid Science Publishers 1995

Authors and Affiliations

  • Carlo La Vecchia
    • 1
    • 2
  • Eva Negri
    • 2
  • Silvia Franceschi
    • 3
  • Adriano Decarli
    • 1
    • 4
  • Attilio Giacosa
    • 5
  • Loren Lipworth
    • 6
  1. 1.Istituto di Statistica Medica e BiometriaUniversita di MilanoMilanoItaly
  2. 2.Istituto di Ricerche Farmacologiche “Mario Negri”MilanoItaly
  3. 3.Servizio di EpidemiologiaCentro di Riferimento OncologicoAviano (PN)Italy
  4. 4.Istituto Nazionale TumoriMilanoItaly
  5. 5.Istituto Nazionale per la Ricerca sul CancroGenovaItaly
  6. 6.Department of EpidemiologyHarvard School of Public HealthBostonUSA
  7. 7.Department of EpidemiologyHarvard School of Public HealthBostonUSA

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