Risk of subsequent cytological abnormality and cancer among women with a history of cervical intraepithelial neoplasia: a comparative study
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.Get Access
A longitudinal study of 1,281 women with a histological diagnosis of cervical intraepithelial neoplasia (CIN) during 1974–76 is presented. After 12 years of follow-up, 30 percent of the women had further cytological abnormalities reported. The rate of subsequent abnormality was highest during the first 12 months of follow-up; thereafter, there was no evidence of any decline in the rate of subsequent abnormality with increasing duration of follow-up. Women from the CIN cohort had twice as many later cytological abnormalities as an age-matched cohort of women who were negatively screened during 1974–76 (excluding abnormalities within 12 months of entry to the study and after adjustment for smear frequency). The CIN cohort remained at substantially greater risk for a subsequent diagnosis of squamous cell carcinoma of the cervix compared with the control group of negatively-screened women (rate ratio 19.8, 95 percent confidence interval 2.4–163.6, P < 0.01). These results indicate that women who have received surgical intervention for CIN continue to have substantial morbidity from cervical abnormalities during medium-term follow-up.
- Jordan JA. Minor degrees of cervical intraepithelial neoplasia. Time to establish a multicentre prospective study to resolve the question [Editorial]. Br Med J 1988 297: 6.
- Parkin DM, Nguyen-Dinh X, Day NE. The impact of screening on the incidence of cervical cancer in England and Wales. Br J Obstet Gynaecol 1985; 92: 150–7.
- Frangopoulou E, Linos A, Mentzelopoulou P, Papaefthimiou M, Efstratiadou M. Changing cytologic detection rates for cervical intraepithelial neoplasia and invasive cancer in a population lacking a mass screening program. Acta Cytol 1989; 33: 839–42.
- Mitchell H, Medley G. Age and time trends in the prevalence of cervical intraepithelial neoplasia on Papanicolaou smears, 1970–1988. Med J Aust 1990; 152: 252–5.
- Hollyock VE, Chanen W. Electrocoagulation diathermy for the treatment of cervical dysplasia and carcinoma in situ. Obstet Gynaecol 1976; 47: 196–9.
- Hemmingsson E, Stendhal U, Stenson S. Cryosurgical treatment of cervical intraepithelial neoplasia with follow-up of five to eight years. Am J Obstet Gynecol 1981; 139: 144–7.
- Chanen W, Rome RM. Electrocoagulation diathermy for cervical dysplasia and carcinoma in situ: a 15-year survey. Obstet Gynaecol 1983; 61: 673–9.
- Arof HM, Gerbie MV, Smeltzer J. Cryosurgical treatment of cervical intraepithelial neoplasia: four-year experience. Am J Obstet Gynecol 1984; 150: 865–9.
- Peter Bryson SC, Lenehan P, Lickrish GM. The treatment of grade 3 cervical intraepithelial neoplasia with cryotherapy: an 11-year experience. Am J Obstet Gynecol 1985; 151: 201–6.
- Woodman CBJ, Jordan JA, Mylotte MJ, Gustafeson R, Wade-Evans T. The management of cervical intraepithelial neoplasia by coagulation diathermy. Br J Obstet Gynaecol 1985; 92: 751–5.
- Deigan EA, Carmichael JA, Ohlke ID, Karchmar J. Treatment of cervical intraepithelial neoplasia with electrocautery: a report of 776 cases. Am J Obstet Gynecol 1986; 154: 255–9.
- Mitchell H, Drake M, Medley G. Prospective evaluation of risk of cervical cancer after cytological evidence of human papillomavirus infection., Lancet 1986; i: 573–5.
- IARC Working Group on evaluation of cervical cancer screening programmes. Screening for squamous cell carcinoma: duration of low risk after negative results of cervical cytology and its implication for screening policies. Br Med J 1986; 293: 659–64.
- EGRET. Seattle: Statistics and Epidemiology Research Corporation (see EGRET User's Manual).
- Rothman KJ, Boice JDJr. Epidemiologic Analysis with a Programmable Calculator. Washington DC: US Govt Printing Office. NIH Publ No 79–1649, 1979.
- Chamberlain J. Reasons that some screening programmes fail to control cervical cancer. In: Hakama M, Miller AB, Day NE, eds. Screening for Cancer of the Uterine Cervix. Lyon: International Agency for Research on Cancer, 1986: 161–8.
- McIndoe WA, McLean MR, Jones RW, Mullins PR. The invasive potential of carcinoma in situ of the cervix. Obstet Gynecol 1984; 64: 451–8.
- Risk of subsequent cytological abnormality and cancer among women with a history of cervical intraepithelial neoplasia: a comparative study
Cancer Causes & Control
Volume 1, Issue 2 , pp 143-148
- Cover Date
- Print ISSN
- Online ISSN
- Kluwer Academic Publishers
- Additional Links
- Cervical cancer
- cervical intraepithelial neoplasia
- Pap smear
- Industry Sectors