Research Papers

Cancer Causes & Control

, Volume 7, Issue 4, pp 428-436

First online:

Nutritional factors and prostate cancer: a case-control study of French Canadians in Montreal, Canada

  • P. GhadirianAffiliated withEpidemiology Research Unit, Research Center
  • , A. LacroixAffiliated withEpidemiology Research Unit, Research CenterLaboratory of Nutrition and Cancer, Research Center
  • , P. MaisonneuveAffiliated withEuropean Institute of Oncology
  • , C. PerretAffiliated withEpidemiology Research Unit, Research Center
  • , G. DrouinAffiliated withDivision of Urology, Research Center
  • , J. P. PerraultAffiliated withDivision of Urology, Saint-Luc Hospital
  • , G. BélandAffiliated withDivision of Urology, Notre-Dame Hospital, Department of Nutrition, Medicine and Surgery, University of Montreal
  • , T. E. RohanAffiliated withNational Cancer Institute of Canada (NCIC), Epidemiology Unit, University of Toronto
  • , G. R. HoweAffiliated withDivision of Epidemiology, Columbia University School of Public Health

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The relationship between the risk of prostate cancer and dietary intake of energy, fat, vitamin A, and other nutrients was investigated in a case-control study conducted in Montreal (Quebec), Canada. French Canadians aged 35 to 84 years with a recent, histologically confirmed diagnosis of adenocarcinoma of the prostate were identified through the admission offices of five major francophone teaching-hospitals in Montreal from 1989 to 1993. Population-based controls matched for age (±five years), language, and place of residence were selected by a modified random-digit dialing method. The study included 232 cases and 231 controls. Information on dietary intake was collected by means of a quantitative dietary history. No association was evident between energy intake and the risk of prostate cancer. In contrast, there was some evidence of an inverse association with intake of total fat, animal fat, monounsaturated fat, and particularly saturated fat (odds ratio = 0.69, 95 percent confidence interval = 0.40–1.18, P=0.05), while a nonsignificant positive association was found with polyunsaturated fat. In addition, high intake of retinol and vegetable protein (highest cf lowest quartile) was associated with reduced risk, but was not statistically significant. No associations were established between intake of other nutrients and risk. These patterns persisted after adjustment for a number of potential confounding factors.

Key words

Diet French Canadians males prostate cancer