Cancer Causes & Control

, Volume 2, Issue 1, pp 3–10

Tobacco, alcohol, and diet in the etiology of laryngeal cancer: a population-based case-control study

  • Witold Zatonski
  • Heiko Becher
  • Jolanta Lissowska
  • Jürgen Wahrendorf
Research Papers

DOI: 10.1007/BF00052355

Cite this article as:
Zatonski, W., Becher, H., Lissowska, J. et al. Cancer Causes Control (1991) 2: 3. doi:10.1007/BF00052355

Cancer of the larynx constitutes an increasingly important problem in Polish males during the last 25 years. A population-based case-control study of laryngeal cancer among people under 65 years of age was conducted in Lower Silesia, a province in Southwest Poland, from 1986 to 1987, with 249 newly-diagnosed cancer cases and 965 controls. The estimated relative risk (RR) for smoking and alcohol are both very high: for smoking more than 30 cigarettes, RR=59.7 (95 percent confidence interval [CI]: 13.0–274); for drinking vodka regularly for more than 30 years, RR=10.4 (95 percent CI: 4.0–27.2). Exposures to alcohol and tobacco show a clear multiplicative effect in all categories of exposure. The risk was shown to be reduced by quitting smoking (RR=0.3, 95 percent CI: 0.14–0.64, after 10 years) or by having a history of intermittent smoking. Poor nutrition was also identified as a strong independent risk factor. However, data quality regarding this factor is not as high as for tobacco and alcohol. Smoking alone accounts in this study for an estimated 95.2 percent of all the cases of laryngeal cancer.

Key words

Alcoholcase-control studylarynxnutritionPolandsmoking

Copyright information

© Rapid Communications of Oxford Ltd 1991

Authors and Affiliations

  • Witold Zatonski
    • 1
  • Heiko Becher
    • 2
  • Jolanta Lissowska
    • 1
  • Jürgen Wahrendorf
    • 2
  1. 1.Cancer Control and Epidemiology DepartmentThe Marie Sklodowska-Curie Memorial Cancer Center and Institute of OncologyWarsawPoland
  2. 2.German Cancer Research CenterInstitute of Epidemiology and BiometryHeidelbergGermany
  3. 3.Institute of Epidemiology and BiometryHeidelbergGermany