Cancer Causes & Control

, Volume 4, Issue 4, pp 345–353

Alcoholic beverage consumption and risk of breast cancer in Spain

  • Jose M. Martin-Moreno
  • Peter Boyle
  • Lydia Gorgojo
  • Walter C. Willett
  • Jesus Gonzalez
  • Fernando Viliar
  • Patrick Maisonneuve
Research Papers

DOI: 10.1007/BF00051337

Cite this article as:
Martin-Moreno, J.M., Boyle, P., Gorgojo, L. et al. Cancer Causes Control (1993) 4: 345. doi:10.1007/BF00051337

The relation between alcoholic beverage consumption and risk of breast cancer was examined. We used data from a population-based, case-control study that included almost all incident cases occurring in five Spanish regions from February 1990 to July 1991. A total of 762 women between 18 and 75 years of age, with a histologically confirmed, first diagnosis of breast cancer, were compared with 988 control women. Alcoholic beverage intake was measured by an interviewer-administered, semiquantitative food-frequency questionnaire. We used ‘nondrinkers’ as the reference category and divided the remainder into four categories according to alcohol intake. The multiple logistic analyses included not only alcohol intake but also possible confounding factors such as total caloric intake, age, socioeconomic status, and reproductive and medical histories. Even at moderate levels of alcohol intake (less than 8 g/day), a 50 percent increase in risk of breast cancer was found. The trend across categories of intake was statistically significant for wine and distilled drinks, as well as total alcohol intake. Consumption of 20 g or more of alcohol per day was associated with a 70 percent elevation in breast cancer risk compared with that of nondrinkers (adjusted relative risk (RR)=1.7,95 percent confidence interval = 1.3–2.3). Although the magnitude of the RR observed in our study was modest, our findings provide further support for a positive association between alcohol consumption and risk of breast cancer.

Key words

Alcoholic beverage consumptionbreast cancercase-control studiesnutritionSpain

Copyright information

© Rapid Communications of Oxford Ltd 1993

Authors and Affiliations

  • Jose M. Martin-Moreno
    • 1
  • Peter Boyle
    • 2
  • Lydia Gorgojo
    • 1
  • Walter C. Willett
    • 3
    • 4
  • Jesus Gonzalez
    • 5
  • Fernando Viliar
    • 5
  • Patrick Maisonneuve
    • 2
  1. 1.Department of Epidemiology and Biostatistics of the “Escucla Nacional de Sanidad”National School of Public HealthMadridSpain
  2. 2.Division of Epidemiology and BiostatisticsEuropean Institute of OncologyMilanItaly
  3. 3.Channing Laboratory, Department of MedicineHarvard Medical SchoolBostonUSA
  4. 4.Department of Epidemiology and NutritionHarvard School of Public HealthBostonUSA
  5. 5.“Direccion General de Salud Publica” of the Spanish Ministry of Health and Consumer AffairsMadridSpain
  6. 6.Department of Epidemiology and BiostatisticsEscuela Nacional de SanidadMadridSpain