Cancer and Metastasis Reviews

, Volume 11, Issue 1, pp 21–30

Hyaluronan and cell locomotion

  • E. A. Turley

DOI: 10.1007/BF00047600

Cite this article as:
Turley, E.A. Cancer Metast Rev (1992) 11: 21. doi:10.1007/BF00047600


Hyaluronan (HA), a glycosaminoglycan, has long been implicated in cell locomotion. We have shown that HA production regulates the locomotion of H-ras-transformed cells. This autocrine motility mechanism is mediated by a novel HA receptor termed RHAMM, an acronym for Receptor for HA Mediated Motility. HA: RHAMM interactions regulate directional locomotion of tumor cells and result in enhanced protein tyrosine phosphorylation that may be a critical messenger mechanism for initiation of locomotion.

Key words

hyaluronanRHAMMdirected cell locomotionprotein tyrosine phosphorylation

Copyright information

© Kluwer Academic Publishers 1992

Authors and Affiliations

  • E. A. Turley
    • 1
    • 2
  1. 1.Monitoba Institute of Cell BiologyUniversity of ManitobaWinnipegCanada
  2. 2.Department of PediatricsUniversity of ManitobaWinnipegCanada