Acta Biotheoretica

, Volume 38, Issue 2, pp 135-142

First online:

On the possible effects of homeostatic shifts in human embryonic development

  • J. Chela-FloresAffiliated withInternational Centre for Theoretical PhysicsDepartamento de Fisica, Universidad Simon Bolivar
  • , C. Espejo AcuiñaAffiliated withHospital Universitario de Caracas, Universidad Central de Venezuela, Ciudad Universitaria

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Possible etiological factors of congenital malformations as well as of human trisomies are considered in the framework of the repressor hypothesis. In this approach gene expression is envisaged from the point of view of the functional variations of the total activation energy for normal gene expression in homeostatic equilibrium. We restrict our attention to variations of the total activation energy under the effect of temperature gradients. We discuss the evidence that hyperthermia may be an etiological factor for trisomies in humans.

Key words

Congenital malformations Development Genetic expression Hyperthermia Repressor hypothesis Trisomies