Acta Biotheoretica

, Volume 38, Issue 2, pp 135–142

On the possible effects of homeostatic shifts in human embryonic development

  • J. Chela-Flores
  • C. Espejo Acuiña

DOI: 10.1007/BF00047550

Cite this article as:
Chela-Flores, J. & Espejo Acuiña, C. Acta Biotheor (1990) 38: 135. doi:10.1007/BF00047550


Possible etiological factors of congenital malformations as well as of human trisomies are considered in the framework of the repressor hypothesis. In this approach gene expression is envisaged from the point of view of the functional variations of the total activation energy for normal gene expression in homeostatic equilibrium. We restrict our attention to variations of the total activation energy under the effect of temperature gradients. We discuss the evidence that hyperthermia may be an etiological factor for trisomies in humans.

Key words

Congenital malformations Development Genetic expression Hyperthermia Repressor hypothesis Trisomies 

Copyright information

© Kluwer Academic Publishers 1990

Authors and Affiliations

  • J. Chela-Flores
    • 1
    • 2
  • C. Espejo Acuiña
    • 3
  1. 1.International Centre for Theoretical PhysicsTriesteItaly
  2. 2.Departamento de FisicaUniversidad Simon BolivarCaracasVenezuela
  3. 3.Hospital Universitario de CaracasUniversidad Central de Venezuela, Ciudad UniversitariaCaracasVenezuela

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