Cancer and Metastasis Reviews

, Volume 9, Issue 3, pp 239–251

Gangliosides, copper ions and angiogenic capacity of adult tissues

  • Pietro M. Gullino
  • Marina Ziche
  • Giulio Alessandri
Article

DOI: 10.1007/BF00046363

Cite this article as:
Gullino, P.M., Ziche, M. & Alessandri, G. Cancer Metast Rev (1990) 9: 239. doi:10.1007/BF00046363

Summary

The report summarizes the work of our laboratory aimed at improving the understanding of the angiogenic response of adult tissues, an event that transforms a micro-embolus of neoplastic cells into a growing metastasis. Attention has been focused on tumor-induced angiogenesis. The following aspects of the subject are discussed: (a) relationship between size of vascular network and tumor growth rate or tumor cell population; (b) angiogenic capacity of tumors and role that prostaglandin E1 may have as an angiogenesis factor; (c) relationship between acquisition of angiogenic capacity and neoplastic transformation of a cell population; (d) modification of tissue composition at the onset of angiogenesis; (e) behaviour of copper ions and copper carriers in the course of the angiogenic response; (f) the influence of gangliosides on endothelial cell motility, survival and growthin vitro; (g) modulation of the angiogenic response by gangliosides (GM1, GT1b)in vivo.

Key words

angiogenesisgangliosidescopperpreneoplasiatumor vascular space

Copyright information

© Kluwer Academic Publishers 1990

Authors and Affiliations

  • Pietro M. Gullino
    • 1
  • Marina Ziche
    • 2
  • Giulio Alessandri
    • 1
  1. 1.Department of Biomedical SciencesUniversity of TurinItaly
  2. 2.Department of PharmacologyUniversity of FlorenceItaly
  3. 3.Dipartimento Scienze BiomedicheTorinoItaly