Abstract
Purpose
This study presents a microfluidic method to generate anisotropic particles from Janus drop with high flexibility to control their shapes by in situ photopolymerization.
Methods
Janus drops are continuously formed as the oil phase breaks up the two laminar flows of a photocurable fluid and a sacrificial template. Our method to generate anisotropic particles includes two routes: In situ polymerization of Janus drop in equilibrium state and evolved drop in nonequilibrium state.
Results
The resulting drop has allowed us to synthesize hemispheres with flat bottom and 3D particles. Also, the formation of the Janus drop and their evolution is theoretically estimated by spreading coefficient.
Conclusions
We anticipate that this novel fabrication approach presented in this work can be applied to produce novel functional material in various applications such as self-assembly, photonics, diagnostics, and drug-delivery.
Similar content being viewed by others
References
Dendukuri D, Doyle PS. The synthesis and assembly of polymeric microparticles using microfluidics. Adv Mater. 2009; 21:4071–4086.
Yang SM, Kim SH, Lim JM, Yi GR. Synthesis and assembly of structured colloidal particles. J Mater Chem. 2008; 18:2177–2190.
Velikov KP, van Dillen T, Polman A, van Blaaderen A. Photonic crystals of shape-anisotropic colloidal particles. Appl Phys Lett. 2002; 81:838–840.
Cederquist KB, Dean SL, Keating CD. Encoded anisotropic particles for multiplexed bioanalysis. Wires Nanomed Nanobi. 2010; 2:578–600.
Champion JA, Katare YK, Mitragotri S. Making polymeric micro- and nanoparticles of complex shapes. P Natl Acad Sci USA. 2007; 104:11901–11904.
Champion JA, Mitragotri S. Role of target geometry in phagocytosis. P Natl Acad Sci USA. 2006; 103:4930–4934.
Lewis CL, Choi CH, Lin Y, Lee CS, Yi H. Fabrication of uniform DNA-conjugated hydrogel microparticles via replica molding for facile nucleic acid hybridization assays. Anal Chem. 2010; 82:5851–5858.
Meiring JE, Schmid MJ, Grayson SM, Rathsack BM, Johnson DM, Kirby R, Kannappan R, Manthiram K, Hsia B, Hogan ZL, Ellington AD, Pishko MV, Willson CG. Hydrogel biosensor array platform indexed by shape. Chem Mater. 2004; 16:5574–5580.
Courbaron A-C, Cayre OJ, Paunov VN. A novel gel deformation technique for fabrication of ellipsoidal and discoidal polymeric microparticles. Chem Commun. 2007; 628–630.
Kim JW, Larsen RJ, Weitz DA. Synthesis of nonspherical colloidal particles with anisotropic properties. J Am Chem Soc. 2006; 128:14374–14377.
Kim JW, Lee D, Shum HC, Weitz DA. Colloid surfactants for emulsion stabilization. Adv Mater. 2008; 20:3239–3243.
Chen CH, Abate AR, Lee DY, Terentjev EM, Weitz DA. Microfluidic assembly of magnetic hydrogel particles with uniformly anisotropic structure. Adv Mater. 2009; 21:3201–3204.
Choi CH, Jung JH, Kim DW, Chung YM, Lee CS. Novel onepot route to monodisperse thermosensitive hollow microcapsules in a microfluidic system. Lab Chip. 2008; 8:1544–1551.
Li W, Pharn HH, Nie Z, MacDonald B, Guenther A, Kumacheva E. Multi-step microfluidic polymerization reactions conducted in droplets: The internal trigger approach. J Am Chem Soc. 2008; 130:9935–9941.
Wan J, Bick A, Sullivan M, Stone HA. Controllable microfluidic production of microbubbles in water-in-oil emulsions and the formation of porous microparticles. Adv Mater. 2008; 20:3314–3318.
Xu S, Nie Z, Seo M, Lewis P, Kumacheva E, Stone HA, Garstecki P, Weibel DB, Gitlin I, Whitesides GM. Generation of monodisperse particles by using microfluidics: Control over size, shape, and composition. Angew Chem Int Edit. 2005; 44:3799.
Dendukuri D, Pregibon DC, Collins J, Hatton TA, Doyle PS. Continuous-flow lithography for high-throughput microparticle synthesis. Nat Mater. 2006; 5: 365–369.
Nisisako T, Torii T. Formation of biphasic janus droplets in a microfabricated channel for the synthesis of shape-controlled polymer microparticles. Adv Mater. 2007; 19:1489–1493.
Xu X, Asher SA. Synthesis and utilization of monodisperse hollow polymeric particles in photonic crystals. J Am Chem Soc. 2004; 126:7940–7945.
Torza S, Mason SG. Three-phase interactions in shear and electrical fields. J Colloid Interf Sci. 1970; 33:67–83.
Glotzer SC, Solomon MJ. Anisotropy of building blocks and their assembly into complex structures. Nat Mater. 2007; 6:557–62.
Choi CH, Yi H, Hwang S, Weitz DA, Lee CS. Microfluidic fabrication of complex-shaped microfibers by liquid templateaided multiphase microflow. Lab Chip. 2011; 11:1477–1483.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Choi, CH., Hwang, S., Jeong, JM. et al. Microfluidic synthesis of anisotropic particles from Janus drop by in situ photopolymerization. Biomed. Eng. Lett. 2, 95–99 (2012). https://doi.org/10.1007/s13534-012-0057-8
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s13534-012-0057-8