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Evaluation of cognitive functions and the related factors in 50–80 year type 2 diabetic subjects

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Abstract

To study cognitive functions in 50–80 year aged type 2 diabetic patients. Cognitive performance was evaluated through a mini mental test (MMT) in 131 patients between 50 and 80 years (100 type 2 diabetics and 31 non-diabetics). Relation analysis were carried out for different parameters. Scores in registration and recall were significantly lower in diabetic group. The effect of HbA1c, body mass index (BMI) and age variables on MMT score was statistically significant. A negative linear correlation was estimated between MMT score and age, HbA1c level and BMI value. HbA1c, age and BMI were inversely related to cognitive functions. MMT scores were 24.98 ± 3.10 in diabetic group and 25.35 ± 3.22 in control group and statistically no significant difference was found. No significant difference was between type 2 diabetics and non-diabetics in terms of cognitive functions. But performance of diabetic patients in relation to the registration and recall was lower. Poor glycemic control and obesity in diabetics negatively affect cognitive performance.

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References

  1. Kahn CR, Weir GC, King GL, Jacobson AM, Moses AC, Smith RJ. Joslin’s diabetes Mellitus. 14th ed. Lippincott Willams-Wilkins; 2005.

  2. Awad N, Gagnon M, Messier C. The relationship between impaired glucose tolerance, type 2 diabetes, and cognitive function. J Clin Exp Neuropsychol. 2004;26:1044–80.

    Article  PubMed  Google Scholar 

  3. Stewart R, Liolitsa D. Type 2 diabetes mellitus, cognitive impairment and dementia. Diabet Med. 1999;16:93–112.

    Article  PubMed  CAS  Google Scholar 

  4. Xu WL, Qui CX, Wahlin A, Winblad B, Fratiglioni L. Diabetes mellitus and risk of dementia in the Kungsholmen project: a 6-year follow-up study. Neurology. 2004;63:1181–6.

    Article  PubMed  CAS  Google Scholar 

  5. Lyketsos CG, Lopez O, Jones B, Fitzpatrick AL, Breitner J, DeKosky S. Prevalence of neuropsychiatric symptoms in dementia and mild cognitive impairment: results from the cardiovascular health study. JAMA. 2002;288:1475–83.

    Article  PubMed  Google Scholar 

  6. Tariot PN, Mack JL, Patterson MB, et al. The behavior rating scale for dementia of the consortium to establish a registry for Alzheimer’s disease. The behavioral pathology committee of the consortium to establish a registry for Alzheimer’s disease. Am J Psychiatry. 1995;152:1349–57.

    Google Scholar 

  7. Folstein MF, Folstein S, Mc Hugh PR. “Mini mental state” a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975;12:189–98.

    Article  PubMed  CAS  Google Scholar 

  8. Güngen C, Ertan T, Eker E, et al. Standardize mini mental test’in Türk Toplumunda Hafif Demans Tanısında Geçerlik ve Güvenilirliği. Türk Psikiyatri Dergisi. 2002;13:273–81.

    Google Scholar 

  9. Wahlin A, Nilsson E, Fastbom J. Cognitive performance in very old diabetic persons: the impact of semantic structure, preclinical dementia, and impending death. Neuropsychology. 2000;16:208–16.

    Article  Google Scholar 

  10. Ott A, Stolk RP, van Harskamp F, Pols HA, Hofman A, Breteler MM. Diabetes mellitus and the risk of dementia: the Rotterdam study. Neurology. 1999;53:1937–42.

    Article  PubMed  CAS  Google Scholar 

  11. Hassing LB, Johansson B, Nilsson SE, Berg S, Pedersen NL, Gatz M, et al. Diabetes mellitus is a risk factor for vasculare dementia, but not for Alzheimer’s disease: a population-based study of the oldest old. İnt Psychogeriatr. 2002;14:77–83.

    Article  Google Scholar 

  12. Biessels GJ, Staekenborg S, Brunner E, Brayne C, Scheltens P. Risk of dementia in diabetes mellitus: a systematic review. Lancet Neurol. 2006;5:64–74.

    Article  PubMed  Google Scholar 

  13. Whitmer RA, Sidney S, Selby J, Johnston SC, Yaffe K. Midlife cardiovascular risk factors and risk of dementia in late life. Neurology. 2005;64:277–81.

    Article  PubMed  CAS  Google Scholar 

  14. Yaffe K, Kanaya A, Lindquist K, Simonsick EM, Haris T, Shorr Rİ, et al. The metabolic syndrome, inflammation, and risk of cognitive decline. LAMA. 2004;292:2237–42.

    Article  CAS  Google Scholar 

  15. Kernan WN, İnzucchi SE, Viscoli CM, Brass LM, Bravata DM, Horwitz Rİ. İnsulin resistance and risk of stroke. Neurology. 2002;59:809–15.

    Article  PubMed  CAS  Google Scholar 

  16. Launer LJ. Diabetes and brain aging: epidemiologic evidence. Curr Diab Rep. 2005;5:59–63.

    Article  PubMed  Google Scholar 

  17. Alex M, Baron EK, Goldenberg S, et al. An autopsy of cerebrovascular accident in diabetes mellitus. Circulation. 1962;25:663–73.

    Article  PubMed  CAS  Google Scholar 

  18. Biessels GJ, Koffeman A, Scheltens P. Diabetes and cognitive impairment. Clinical diagnosis and brain imaging in patients attending a memory clinic. J Neurol. 2006;253:477–82.

    Google Scholar 

  19. Biessels GJ, Kamal A, Ramakers GM, Urban İJ, Spruijt BM, Erkelens DW, et al. Place learning and hippocampal synaptic plasticity in streptozotocin-induced diabetic rats. Diabetes. 1996;45:1259–66.

    Article  PubMed  CAS  Google Scholar 

  20. Smith MA, Sayre LM, Monnier VM, Perry G. Radical Ageing in Alzheimer’s disease. Trends Neurosci. 1995;18:172–6.

    Article  PubMed  CAS  Google Scholar 

  21. Yaffe K, Blackwell T, Kanaya AM, Davidowitz N, Barrett-Connor E, Krueger K. Diabetes, impaired fasting glucose, and development of cognitive impairment in older women. Neurology. 2004;63:658–63.

    Article  PubMed  CAS  Google Scholar 

  22. Vanhanen M, Koivisto K, Kuusisto J, Mykkanen L, Helkala EL, Hanninen T, et al. Cognitive fonction in an elderly population with persistent impaired glucose tolerance. Diabetes Care. 1998;21:398–402.

    Article  PubMed  CAS  Google Scholar 

  23. Xu W, Qui C, Winblad B, Fratiglioni L. The effect of borderline diabetes on the risk of dementia and Alzheimer’s disease. Diabetes. 2007;56:211–6.

    Article  PubMed  CAS  Google Scholar 

  24. van den Berg E et al. Cognitive fonctioning in elderly persons with type 2 diabetes and metabolic syndrome: the Hoorn study. Dement Geriatr Cogn Disord. 2008;26:261–9.

    Article  PubMed  Google Scholar 

  25. Dik MG, Jonker C, Comijs HC, Deeg DJ, Kok A, Yaffe K, et al. Contribution of metabolic syndrome components to cognition in older individuals. Diabetes Care. 2007;30:2655–60.

    Article  PubMed  Google Scholar 

  26. Kalmijn S, Foley D, White L, Burchfiel CM, Curb JD, Petrovitch H, et al. Metabolic cardiovascular syndrome and risk of dementia in Japanese American elderly men. The Honolulu-Asia aging study. Arterioscler Thromb Vasc Biol. 2000;20:2255–60.

    Article  PubMed  CAS  Google Scholar 

  27. Muller M, Tang MX, Schupf N, Manly JJ, Mayeux R, Lunchsinger JA. Metabolic syndrome and dementia risk in multiethnic elderly cohort. Dement Geriatr Cogn Disord. 2007;24:185–92.

    Article  PubMed  Google Scholar 

  28. Peila R, Rodriguez BL, White LR, Launer LJ. Fasting insulin and incident dementia in an elderly population of Japanese-American men. Neurology. 2004;63:228–33.

    Article  PubMed  CAS  Google Scholar 

  29. Komulainen P, Lakka TA, Kivipelto M, Hassinen M, Helkala EL, Haapala I, et al. Metabolic syndrome and cognitive function: a population – based follow-up study in elderly women. Dement Geriatr Cogn Disord. 2007;23:29–34.

    Article  PubMed  Google Scholar 

  30. Xiong GL, Plassman BL, Helms MJ, Steffens DC. Vascular risk factors and cognitive decline among elderly male twins. Neurology. 2006;67:1586–91.

    Article  PubMed  Google Scholar 

  31. Yaffe K. Metabolic syndrome and cognitive disorders: is the sum greater than its parts? Alzheimer Dis Assoc Disord. 2007;21:167–71.

    Article  PubMed  Google Scholar 

  32. Brands AM, Biessels GJ, De Haan EH, Kappelle LJ, Kessels RP. The effects of type 1 diabetes on cognitive performance: a meta analysis. Diabetes Care. 2005;28:726–35.

    Article  PubMed  Google Scholar 

  33. Jacobson AM, Musen G, Ryan CM, Silvers N, Cleary P, Waberski B, et al. Long-term effect of diabetes and its treatment on cognitive function. N Engl J Med. 2007;356:1842–52.

    Article  PubMed  Google Scholar 

  34. Peila R, Rodriguez BL, Launer LJ. Type 2 diabetes, APOE gene, and the risk for dementia and related pathologies: the Honolulu –Asia aging study. Diabetes. 2002;51:1256–62.

    Article  PubMed  CAS  Google Scholar 

  35. Yaffe K, Blackwell T, Whitmer RA, Krueger K, Baret CE. Glycosylated hemoglobin level and development of mild cognitive impairment or demetia in older women. J Nutr Health Aging. 2006;10:293–5.

    PubMed  CAS  Google Scholar 

  36. Yaffe K, Blackwell T, Whitmer RA, et al. Glycosylated hemoglobin level and development of mild cognitive impairment or dementia in older women. J Nutr Health Aging. 2006;10:293–5.

    Google Scholar 

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Authors and Affiliations

  1. Okmeydani Training and Research Hospital, Sisli, Istanbul, Turkey

    Mustafa Temizel

  2. Department of Internal Medicine, Okmeydani Training and Research Hospital, Istanbul, Turkey

    Meral Mert, Hakan Yanar, Yucel Arman, Kadem Arslan, Feride Alakus & Ebru Ayozturk Velioglu

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  1. Mustafa Temizel
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  2. Meral Mert
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  3. Hakan Yanar
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  4. Yucel Arman
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Correspondence to Mustafa Temizel.

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Temizel, M., Mert, M., Yanar, H. et al. Evaluation of cognitive functions and the related factors in 50–80 year type 2 diabetic subjects. Int J Diabetes Dev Ctries 33, 71–74 (2013). https://doi.org/10.1007/s13410-013-0126-2

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  • DOI: https://doi.org/10.1007/s13410-013-0126-2

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