Abstract
Rapidly evolving advances in the field of immunology over the last few decades have impacted the practice of clinical medicine in many ways. In fact, understanding the immunological basis of disease has been pivotal in deciphering the pathogenesis of several disease processes, infective or otherwise. As of today, there is hardly any specialty of medicine which is not influenced by immunology. Pediatric rheumatological disorders, vasculitides, Human Immunodeficiency Virus (HIV) infection, Primary Immunodeficiency Diseases (PIDs) and autoimmune disorders fall under the domain of clinical immunology. This specialty is poised to emerge as a major clinical specialty in our country. The gulf between bench and bedside is narrowing down as our understanding of the complex immunological mechanisms gets better. However, a lot still needs to be done in this field as the morbidity and mortality of some of these conditions is unacceptably high in the Indian setup. A number of medical schools and institutes in the country now have the resources and the wherewithal to develop into specialized centres of clinical immunology. We need to concentrate on training more physicians and pediatricians in this field. The future is bright and the prospects exciting!
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Clinical Immunology: Guidelines for its Organization, Training and Certification; Relationships With Allergology and Other Medical Disciplines-A WHO/IUIS/IAACI Report. Clin Exp Immunol. 1993;93:484–491.
Shearer WT. Recognition of clinical immunology as a distinct medical subspecialty. J Allergy Clin Immunol. 2002;110:567–570.
Thompson RA. Clinical immunology: is it clinical science or medical practice? Clin Exp Immunol. 1993; 93:299–300.
Petty RE, Cassidy JT. Chronic arthritis in childhood. In: Cassidy JT, Petty RE, Laxer RM, Lindsley C (Eds), Textbook of Pediatric Rheumatology, 6th edition, Philadelphia: Saunders Elseviers; 2011. p. 505–520.
Singh S, Aulakh R, Bhalla AK, Suri D, Manojkumar R, Narula N, et al. Is Kawasaki disease incidence rising in Chandigarh, North India? Arch Dis Child. 2011;96: 137–140.
Singh S, Aulakh R. Kawasaki disease and Henoch Schonlein purpura: changing trends at a tertiary care hospital in north India (1993–2008). Rheumatol Int. 2010;30:771–774.
Singh S, Kawasaki T. Kawasaki disease - an Indian perspective. Indian Pediatr. 2009;46:563–571.
Singh S, Bansal A, Gupta A, Manojkumar R, Mittal BR. Kawasaki Disease — a decade of experience from North India. Int Heart J. 2005;46:679–689.
Singh S, Gupta MK, Bansal A, Kumar RM, Mittal BR. A comparison of the clinical profile of Kawasaki disease in children from Northern India above and below 5 years of age. Clin Exp Rheumatol. 2007;25:654–657.
Singh S, Dayal D, Minz RW, Joshi K, Datta U, Kumar L. Severe Henoch-Schonlein nephritis: treatment with azathioprin and steroids. Rheumatol Int. 2002;22:133–137.
Mahajan N, Bisht D, Dhawan V, Singh S, Minz R. Transcriptional expression and gelatinolytic activity of matrix metalloproteinases in Henoch-Schonlein purpura. Acta Paediatrica. 2010;99: 1248–1252.
Uehara R. Epidemiologic features of Kawasaki disease in Japan, 2007–2010. Pediatr Int. 2012;54:38.
National AIDS Control Organization. Annual Report 2010–11. Ministry of Health and Family Welfare, Government of India.
Singh S, Jat KR, Minz RW, Arora S, Suri D, Sehgal S. Clinical profile of 516 children affected by HIV in a tertiary care centre in Northern India: 14 years of experience. Trans Royal Soc Trop Med Hyg. 2009;103:627–633.
Minz RW, Singh S, Varma S, Mathuria SN, Aggrawal R, Sehgal S. Relevance of opt-out screening for HIV in emergency and pre-surgery patients in a tertiary care center in Northern India: A pilot study. Indian J Pathol Microbiol. 2010;53:287–289.
Al-herz W, Bousfiha A, Casanova J, Chapel H, Conley M, Cunningham-Rundles C, et al. Primary Immunodeficiency Diseases: an update on the classification from the International Union of Immunological Societies Expert Committee for Primary Immunodeficiency. Frontier Immun;2:54.doi:10.3389/fimmu.2011.00054.
Gupta S, Madkaikar M, Singh S, Sehgal S. Primary immunodeficiencies in India: a perspective. Ann N Y Acad Sci. 2012;1250:73–79.
Suri D, Singh S, Rawat A, Gupta A, Kamae C, Honma K, et al. Clinical profile and genetic basis of Wiskott-Aldrich syndrome at Chandigarh, North India. Asian Pac J All Immunol. 2012;30:71–78.
Chandrakasan S, Singh S, Dogra S, Delaunay J, Proust A, Minz RW. Wiskott-Aldrich syndrome presenting with early onset recurrent acute hemorrhagic edema and hyperostosis. Pediatr Bl Cancer. 2011;56:1130–1132.
Rawat A, Singh S, Sharma D, Suri D, Rajwanshi A, Etzioni A. Amyloidosis in a child with Leucocyte adhesion deficiency type-1: an unusual association. Indian J Pediatr. 2011;78:1546–1548.
Bal A, Rawat A, Nada R, Singh S. A 12-year-old boy with X-linked agammaglobulinemia who had breakthrough infection, thrombocytopenia and acute renal failure. Natl Med J India. 2009;22: 310–316.
Nampoothiri S, Singh S, Nampoothiri KN, Boisson-Dupuis S, Abel L, Casanova JL. Multifocal tuberculous osteomyelitis: possible inherited interferon gamma axis Defect. Indian J Pediatr. 2012 Feb 29. [Epub ahead of print].
Minz RW, Kumar Y, Anand S, Singh S, Bamberi P, Verma S, Sehgal S. Antinuclear antibody positive autoimmune disorders in North India: an appraisal. Rheumatol Int. 2012;32:2883–2888.
Minz RW, Chhabra S, Rani L, Singh S, Jindal SK, Sakhuja V. A decade long experience of anti-neutrophil cytoplasmic antibody testing in a tertiary care referral center in North India: Perspective from a developing country. Indian J Path Microbiol. 2011;54:258–263.
Minz RW, Chhabra S, Singh S, Radotra BD, Kumar B. Direct immunofluorescence of skin biopsy: perspective of an immunopathologist. Indian J Dermatol Venereol Leprol. 2010;76:150–157.
Baker MW, Grossman WJ, Laessig RH, Hoffman GL, Brokopp CD, Kurtycz DF, et al. Development of a routine newborn screening protocol for severe combined immunodeficiency. J Allergy Clin Immunol. 2009; 124:522–527.
Nakagawa N, Imai K, Kanegane H, Sato H, Yamada M, Kondoh K. et al. Quantification of κ-deleting recombination excision circles in Guthrie cards for the identification of early B-cell maturation defects. J Allergy Clin Immunol. 2011;128:223–225.
Pessach IM, Notarangelo LD. Gene therapy for primary immunodeficiencies: looking ahead, toward gene correction. J Allergy Clin Immunol. 2011;127:1344–1350.
Fischer A, Hacein-Bey-Albina S, Cavazzana-Calvo M. Gene therapy for primary adaptive immune deficiencies. J Allergy Clin Immunol. 2011;127:1356–1359.
Wallace CA, Giannini EH, Spalding SJ, Hashkes PJ, O’Neil KM, Zeft AS, et al. Trial of early aggressive therapy in polyarticular juvenile idiopathic arthritis. Arthritis Rheum. 2012;64:2012–2021.
Aggarwal P, Singh S, Suri D, Rawat A, Narula N, Manojkumar R. Rituximab in childhood lupus myocarditis. Rheumatol Int. 2012;32:1843–1844.
Rana A, Minz R, Aggarwal R, Anand S, Pasricha N, Singh S. Gene expression of cytokines (TNF-α, IFN-γ), serum profiles of IL-17 and IL-23 in paediatric systemic lupus erythematosus. Lupus. 2012;10:1105–112.
Singh S, Chandrakasan S, Ahluwalia J, Suri D, Rawat A, Ahmed N, et al. Macrophage activation syndrome in children with systemic onset juvenile idiopathic arthritis: clinical experience from northwest India. Rheumatol Int. 2012;32:881–886.
Singh S, Gupta MK, Ahluwalia J, Singh P, Malhi P. Neuropsychiatric manifestations and antiphospholipid antibodies in pediatric onset lupus: 14 years of experience from a tertiary care centre of North India. Rheumatol Int. 2009;29:1455–1461.
Salhan M, Ahluwalia J, Singh S, Minz R. Antiphospholipid antibodies in children with Henoch Schonlein Purpura — a prospective study from North India. Scand J Rheumatol. 2007;36:482–484.
Singh S, Dayal D, Kumar L, Joshi K. Mortality patterns in childhood lupus — 10 years experience in a developing country. Clin Rheumatol. 2002;21:462–465.
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Singh, S., Gupta, A. & Rawat, A. 50 years of Pediatric Immunology: Progress and future — A clinical perspective. Indian Pediatr 50, 88–92 (2013). https://doi.org/10.1007/s13312-013-0020-5
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DOI: https://doi.org/10.1007/s13312-013-0020-5