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Pioglitazone prescription increases risk of bladder cancer in patients with type 2 diabetes: an updated meta-analysis

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Tumor Biology

Abstract

Pioglitazone is widely used for glycemic control in patients with type 2 diabetes mellitus, but evidence regarding the association between pioglitazone and bladder cancer risk is confusing. A systematic search of databases was carried out, and other relevant papers were also identified. Then, the analyses were conducted according to the PRISMA and MOOSE guidelines. After quality assessment, nine datasets from 10 available studies were included on the basis of inclusion criteria. The incidence of bladder cancer among pioglitazone ever users and never users, pooled from four cohort and one randomized studies, were 84.51 and 66.68 per 100,000 person-years, respectively. Nine studies representing 2,596,856 diabetic patients were recognized as eligible for overall study; the result suggested an increased risk of bladder cancer in patients exposed to pioglitazone. A persistent significance was detected after being adjusted by age, gender, and use of other diabetes medications. Subgroup analyses indicated that the significantly increased incidence of bladder cancer was found in men, but not in women. Additionally, the analyses addressing increasing exposure to pioglitazone observed a dose–response relation between exclusive ever use of pioglitazone and bladder cancer in terms of cumulative duration of use and cumulative dosage. With some limitations, our results suggest an increased risk of bladder cancer in diabetic patients using pioglitazone, especially for men with long-term and high-dose exposure. Additional studies are needed to provide more precise evidences to support our results.

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Acknowledgments

The authors thank all of the authors of primary studies included in their meta-analyses.

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Authors and Affiliations

  1. Department of Urology, Wu Qing District People’s Hospital, Tianjin, China

    Shiyao He

  2. College of Laboratory Medicine, Hebei North University, Zhangjiakou, 075000, China

    Yu-hong Tang

  3. Department of Urology, The First Affiliated Hospital of Hebei North University, Zhangjiakou, 075000, China

    Guobin Zhao

  4. Department of Urology, Affiliated Hospital of Yan’an University, Yanan, 716000, China

    Xiaolong Yang, Dehou Wang & Ye Zhang

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  1. Shiyao He
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  2. Yu-hong Tang
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  6. Ye Zhang
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Correspondence to Ye Zhang.

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He, S., Tang, Yh., Zhao, G. et al. Pioglitazone prescription increases risk of bladder cancer in patients with type 2 diabetes: an updated meta-analysis. Tumor Biol. 35, 2095–2102 (2014). https://doi.org/10.1007/s13277-013-1278-x

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  • DOI: https://doi.org/10.1007/s13277-013-1278-x

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