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Downregulation of programmed cell death 4 (PDCD4) in tumorigenesis and progression of human digestive tract cancers

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Tumor Biology

Abstract

Nowadays, digestive tract cancers become the commonest neoplasia and one of the leading causes of cancer deaths worldwide. The development of diagnosis and therapy is urgently required. Programmed cell death 4 (PDCD4), a new tumor suppressor, has been documented to be a potential diagnostic tool and treatment target for neoplasia due to the inhabitation of tumor promotion/progression and metastasis. However, its role in human digestive tract cancers is few available up to now. In this study, we examined the expression of PDCD4 in human digestive tract cancers (61 gastric cancer, 65 colorectal cancer, and 69 pancreatic cancer patients) by Western blot analysis, reverse transcription (RT)-PCR, and immunohistochemistry. Western blot, RT-PCR, and immunohistochemistry examination showed that expressions of PDCD4 were significantly lower in cancers specimens than in noncancerous tissues. Among the different differentiated cancer tissues, PDCD4 expression was significantly lower in moderately or poorly differentiated cancers than in well-differentiated cancers (p < 0.05). Our findings suggested that PDCD4 might be a potentially valuable molecular target in diagnosis and therapy for human digestive tract cancers.

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Acknowledgments

This work was supported by the National Natural Science Foundation of China (No.30572114).

Conflict of interest

The authors declare that they have no conflict of interests.

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Authors and Affiliations

  1. Department of Surgery, First Affiliated Hospital, China Medical University, Shenyang, People’s Republic of China

    Gang Ma, Hao Zhang, Ming Dong, Xinyu Zheng & Kejian Guo

  2. Division of Hepatology and Metabolism, Department of internal Medicine, Saga Medical School, Saga University, Saga, Japan

    Iwata Ozaki

  3. Health Administration Center, Saga Medical School, Saga University, Saga, Japan

    Sachiko Matsuhashi

Authors
  1. Gang Ma
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  2. Hao Zhang
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  3. Ming Dong
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  4. Xinyu Zheng
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  5. Iwata Ozaki
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  6. Sachiko Matsuhashi
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  7. Kejian Guo
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Corresponding author

Correspondence to Gang Ma.

Additional information

Gang Ma and Hao Zhang contributed equally to this study.

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Ma, G., Zhang, H., Dong, M. et al. Downregulation of programmed cell death 4 (PDCD4) in tumorigenesis and progression of human digestive tract cancers. Tumor Biol. 34, 3879–3885 (2013). https://doi.org/10.1007/s13277-013-0975-9

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  • DOI: https://doi.org/10.1007/s13277-013-0975-9

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